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| | 4-(2-Aminoethyl)morpholine Basic information |
| | 4-(2-Aminoethyl)morpholine Chemical Properties |
| Melting point | 24 °C | | Boiling point | 205 °C(lit.) | | density | 0.992 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.476(lit.) | | Fp | 347 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Chloroform, Methanol | | pka | pK1: 4.06(+2);pK2: 9.15(+1) (25°C) | | form | Liquid After Melting | | color | Clear colorless to pale yellow | | Water Solubility | soluble | | Sensitive | Air Sensitive | | BRN | 104378 | | Stability: | Air Sensitive | | InChIKey | RWIVICVCHVMHMU-UHFFFAOYSA-N | | CAS DataBase Reference | 2038-03-1(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Morpholineethanamine(2038-03-1) | | EPA Substance Registry System | 4-Morpholineethanamine (2038-03-1) |
| Hazard Codes | C,T | | Risk Statements | 22-34-43-24-40-23/24/25 | | Safety Statements | 26-36/37/39-45-22 | | RIDADR | UN 2735 8/PG 2 | | WGK Germany | 2 | | RTECS | QD7350000 | | Hazard Note | Toxic | | TSCA | Yes | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29349990 | | Toxicity | guinea pig,LD50,skin,300uL/kg (0.3mL/kg),Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 269, 1944. |
| | 4-(2-Aminoethyl)morpholine Usage And Synthesis |
| Chemical Properties | clear colorless to pale yellow liq. after melting | | Uses | 4-(2-Aminoethyl)morpholine is widely used in biomedical applications as this moiety serves as an important lysosome-targeting group. Some of its applications include:
- Synthesis of the lysosome-targetable fluorescent probe for hydrogen sulfide imaging in living cells.
- Synthesis of 1,8-naphthalimide conjugated Troger′s bases as deoxyribonucleic acid (DNA) targeting fluorescent probe.
- Synthesis of intramolecular charge transfer-photoinduced electron transfer-fluorescence resonance energy transfer (ICT-PET-FRET) fluorescent probe for monitoring pH changes in living cells.
- It is also used as a precursor to synthesize a variety of antimicrobial agents.
| | Uses | 4-(2-Aminoethyl)morpholine is used as a ligand and reacts with nickel(II) nitrite to form trans-bis[4-(2-aminoethyl)morpholine]dinitronickel(II). | | Definition | ChEBI: 4-2-Aminoethyl-morpholine is a member of morpholines. | | Synthesis Reference(s) | Journal of Medicinal Chemistry, 34, p. 1805, 1991 DOI: 10.1021/jm00110a008 |
| | 4-(2-Aminoethyl)morpholine Preparation Products And Raw materials |
| Preparation Products | 1-CYCLOHEXYL-3-(2-MORPHOLINOETHYL)CARBODIIMIDE METHO-P-TOLUENESULFONATE-->Acetamide, 2-amino-N-[2-(4-morpholinyl)ethyl]--->Carbamic acid, N-[2-(4-morpholinyl)ethyl]-, 2,2,2-trifluoroethyl ester-->2-CYANO-N-(2-MORPHOLIN-4-YL-ETHYL)-ACETAMIDE-->4-(2-[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PHENOXY]-ETHYL)-MORPHOLINE-->4-[2-(4-MORPHOLINO)ETHYL]-3-THIOSEMICARBAZIDE-->4-[2-(Dimethylamino)ethyl]morpholine |
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