APETx2
中文名称 | APETx2 |
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中文同义词 | APETX2毒素肽;毒素多肽APETX2;海葵肽抑制剂;H-GLY-THR-ALA-CYS-SER-CYS-GLY-ASN-SER-LYS-GLY-ILE-TYR-TRP-PHE-TYR-ARG-PRO-SER-CYS-PRO-THR-ASP-ARG-GLY-TYR-THR-GLY-SER-CYS-ARG-TYR-PHE-LEU-GLY-THR-CYS-CYS-THR-PRO-ALA-ASP-OH(DISULFIDE BRIDGE:CYS4-CYS37;CYS6-CYS30;CYS20-CYS38);肽毒素多肽;APETX2,可逆ASIC3通道阻塞器 |
英文名称 | APETx2 |
英文同义词 | APETx2;2-[2-[[1-[2-[[52-[2-[[2-[(2-aminoacetyl)amino]-3-hydroxybutanoyl]amino]propanoylamino]-34-(4-aminobutyl)-40-(2-amino-2-oxoethyl)-19,69-dibenzyl-28-butan-2-yl-13,75,96-tris(3-carbamimidamidopropyl)-99-(carboxymethyl)-2~{a},60,87-tris(1-hydroxyethyl)-4,37,49,81-tetrakis(hydroxymethyl)-16,25,72,90-tetrakis[(4-hydroxyphenyl)methyl]-22-(1~{H}-indol-3-ylmethyl)-66-(2-methylpropyl)-1~{a},3,4~{a},6,10~{a},12,15,17~{a},18,21,24,27,30,33,36,39,42,45,48,51,59,62,65,68,71,74,77,80,83,86,89,92,95,98-tetratriacontaoxo-12~{a},13~{a},19~{a},20~{a},54,55-hexathia-~{a},2,3~{a},5,9~{a},11,14,16~{a},17,20,23,26,2;APETx2 USP/EP/BP;Cys20-Cys38);Cys6-Cys30;H-Gly-Thr-Ala-Cys-Ser-Cys-Gly-Asn-Ser-Lys-Gly-Ile-Tyr-Trp-Phe-Tyr-Arg-Pro-Ser-Cys-Pro-Thr-Asp-Arg-Gly-Tyr-Thr-Gly-Ser-Cys-Arg-Tyr-Phe-Leu-Gly-Thr-Cys-Cys-Thr-Pro-Ala-Asp-OH(Disulfide bridge:Cys4-Cys37 |
CAS号 | 713544-47-9 |
分子式 | C196H280N54O61S6 |
分子量 | 0 |
EINECS号 | |
相关类别 | 毒素肽;目录肽 |
Mol文件 | Mol File |
结构式 |
APETx2 性质
储存条件 | Store at -20°C |
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形态 | 粉末 |
水溶解性 | Soluble to 5 mg/ml in water |
APETx2是一种高纯度,合成且具有生物活性的肽毒素。APETx2 是可来自Anthopleura elegantissima 的海葵肽,是选择性的、可逆的酸敏感的离子通道 ASIC3 (acid-sensing ion channel) 抑制剂,其 IC50 值为 63 nM. APETx2 作用在 ASIC3 通道外部。APETx2 能够逆转酸性诱导的炎症疼痛。
APETx2 (i.t. or i.m. application, 0.022 to 2.2 µM) resulted in a potent and complete reversal of established mechanical hypersensitivity in the complete Freund's adjuvant (CFA) inflammatory pain model.