N,N,2-三甲基-5-硝基苯磺酰胺
| 中文名称 | N,N,2-三甲基-5-硝基苯磺酰胺 |
|---|---|
| 中文同义词 | N,N,2-三甲基-5-硝基苯磺酰胺;化合物BRL 50481 |
| 英文名称 | BRL 50481 |
| 英文同义词 | 5-NITRO-2,N,N-TRIMETHYLBENZENESULFONAMIDE;BRL 50481;N,N,2-TRIMETHYL-5-NITRO-BENZENESULFONAMIDE;3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene,5-Nitro-2-N,N-trimethylbenzenesulfonamide;Benzenesulfonamide, N,N,2-trimethyl-5-nitro-;-50481 |
| CAS号 | 433695-36-4 |
| 分子式 | C9H12N2O4S |
| 分子量 | 244.27 |
| EINECS号 | 1592732-453-0 |
| 相关类别 | 合成;All Inhibitors;Inhibitors;Cyclic Nucleotide related |
| Mol文件 | 433695-36-4.mol |
| 结构式 |  |
N,N,2-三甲基-5-硝基苯磺酰胺 性质
| 熔点 | 65-67°C |
|---|---|
| 沸点 | 391.1±52.0 °C(Predicted) |
| 密度 | 1.334±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 在DMSO中的溶解度为12 毫克/毫升 |
| 形态 | 固体 |
| 酸度系数(pKa) | -5?+-.0.70(Predicted) |
| 颜色 | 白色 |
| 稳定性 | 从购买之日起 2 年内保持稳定。 DMSO 或乙醇溶液可在 -20℃ 下保存长达 3 个月。 |
IC50: 0.15 μM (PDE7A), 12 μM (PDE7B), 62 μM (PDE4), 490 μM (PDE3)
BRL-50481 increases the cAMP content (19.1±6.2% of IBMX response at 300 μM) but is considerably less potent. BRL-50481 (30 μM) fails to suppress proliferation by itself but significantly potentiates the effect of rolipram. BRL-50481 (30 μM) has no effect on IL-15-induced proliferation but augments the inhibitory effect of rolipram. Pretreatment (30 min) of human monocytes with BRL-50481 has, by itself, a negligible (~2 to 10%) inhibitory effect on TNFα output at all concentrations tested. BRL-50481 also potentiates the inhibitory effect of PGE 2 on LPS-induced TNFα release. BRL-50481 has no significant effect by itself on κB-dependent transcription (5.6±1.9% inhibition at 30 μM) and fails to enhance the effect of rolipram (maximum inhibition, 52.9±2.7%; pIC 30 value of 5.33±0.12). BRL-50481 suppresses, in a concentration-dependent manner, LPS-induced TNFα release in monocytes in which PDE7A1 is induced (21.7±1.6% inhibition at 30 μM at the 12-h time point).
安全信息
| WGK Germany | 3 |
|---|---|
| 海关编码 | 2935.90.9500 |
| 提供商 | 语言 |
|---|---|
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | T3112 | N,N,2-三甲基-5-硝基苯磺酰胺 N,N,2-Trimethyl-5-nitrobenzenesulfonamide | 433695-36-4 | 200mg | 150元 |
| 2024/04/30 | HY-109586 | N,N,2-三甲基-5-硝基苯磺酰胺 BRL-50481 | 433695-36-4 | 5mg | 500元 |