CKI-7
| 中文名称 | CKI-7 |
|---|---|
| 中文同义词 | 化合物 T10829 |
| 英文名称 | CKI-7 |
| 英文同义词 | 8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro- Dihydrochloride;8-[N-(2-Aminoethyl)sulphamoyl]-5-chloroisoquinoline, CKI-7;N-(2-AMinoethyl)-5-chloro-isoquinolin-8-sulphonaMide;N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide;CKI-7 free base;8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro-;CKI 7 free base,CKI7 free base |
| CAS号 | 120615-25-0 |
| 分子式 | C11H12ClN3O2S |
| 分子量 | 285.75 |
| EINECS号 | |
| 相关类别 | Inhibitors;Protein Kinase Inhibitors and Activators;All Inhibitors |
| Mol文件 | 120615-25-0.mol |
| 结构式 |  |
CKI-7 性质
| 熔点 | 188-190°C |
|---|---|
| 沸点 | 499.7±55.0 °C(Predicted) |
| 密度 | 1.432±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | H2O:9 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 7.80±0.50(Predicted) |
| 颜色 | 白色 |
|
CK1 6 μM (IC 50 ) |
CK1 8.5 μM (Ki) |
Cdc7
|
SGK
|
S6K1
|
MSK1
|
CKI-7 (0.1-10 μM; 5 days; ES cells) treatment significantly increases the expression of the early neuroectodermal marker Sox1 and the number of cells positive for the neural markers nestin and βIII-tubulin, in a concentration-dependent manner.
CKI-7 (5 μM; 5 days; ES cells) treatment suppresses SFEB-induced β-catenin stabilization on day 5, indicating that CKI-7 inhibits Wnt signaling.
RT-PCR
| Cell Line: | Mouse ES cells |
| Concentration: | 0.1-10 μM |
| Incubation Time: | 5 days |
| Result: | Significantly increased the expression of the early neuroectodermal marker Sox1 and the number of cells positive for the neural markers nestin and βIII-tubulin, in a concentration-dependent manner. |
Western Blot Analysis
| Cell Line: | Mouse ES cells |
| Concentration: | 5 μM |
| Incubation Time: | 5 days |
| Result: | Suppressed SFEB-induced β-catenin stabilization on day 5. |
In vivo dose-dependent anti-tumor activity of CKI-7 is demonstrated in a SCID-Beige mouse systemic tumor model utilzing a recently isolated Philadelphia chromosome positive acute lymphoblastic leukemia cell line. Standard cell cycle synchronization studies established that exposure to CKI-7 results in cell cycle dependent caspase 3 activation and apoptotic cell death.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-133028 | CKI-7 CKI-7 free base | 120615-25-0 | 5mg | 850元 |
| 2024/04/30 | HY-133028 | CKI-7 CKI-7 free base | 120615-25-0 | 10mg | 1500元 |