| 中文名称 | Calcitonin Gene Related Peptide (CGRP) (83-119), rat |
|---|---|
| 中文同义词 | |
| 英文名称 | Calcitonin Gene Related Peptide (CGRP) (83-119), rat |
| 英文同义词 | Calcitonin Gene Related Peptide (CGRP) (83-119), rat |
| CAS号 | |
| 分子式 | C???H???N??O??S? |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | Mol File |
| 结构式 |
Calcitonin Gene Related Peptide (CGRP) (83-119), rat 性质
CRLR
Calcitonin Gene Related Peptide (CGRP) (83-119), rat belongs to the calcitonin family of neuropeptides which also includes adrenomedullin, amylin, calcitonin, intermedin and calcitonin receptor-stimulating peptide. Calcitonin Gene Related Peptide (CGRP) has two isoforms (αCGRP and βCGRP), and acts through calcitonin receptor-like receptor (CRLR). Calcitonin Gene Related Peptide (CGRP) plays a key role in migraine pathophysiology and is associated with activation of the trigeminovascular system. CGRP prossibly acts postjunctionally in these areas putatively involved in primary headaches.
CGRP is a potent inducer of oedema in rat orofacial tissue. CGRP (100 μL; 8-33 pmol) induces a rapidly developing (5-15 min) and long-lasting (6 h), dose-dependent oedema in the rat cheek. CGRP induces a smaller oedematogenic effect in the rat hind paw also blocked by the CGRP antagonist. CGRP (16 pmol) potentiates the oedema induced by co-injected substance P (3.7 nmol).