Company Name: |
J & K SCIENTIFIC LTD.
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Tel: |
010-82848833 400-666-7788 |
Email: |
jkinfo@jkchemical.com |
Products Intro: |
Product Name:4-alpha-Phorbol 12-Myristate 13-Acetate >99% CAS:63597-44-4 Package:1mg, 5mg, 10mg
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Company Name: |
Sigma-Aldrich
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Tel: |
021-61415566 800-8193336 |
Email: |
orderCN@merckgroup.com |
Products Intro: |
Product Name:4α-Phorbol 12-myristate 13-acetate CAS:63597-44-4 Purity:>=95% (TLC) Package:1mg, 5mg Remarks:P148
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Company Name: |
Shanghai Han-Xiang Chemical Co., Ltd.
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Tel: |
15971444841 |
Email: |
amber@biochempartner.com |
Products Intro: |
Product Name:4α-Phorbol 12-myristate 13-acetate CAS:63597-44-4 Purity:98% HPLC LCMS Package:1G;100G
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| 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Basic information |
Product Name: | 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE | Synonyms: | 4-A-PHORBOL 12-MYRISTATE-13-ACETATE NEGA TIVE CONTROL;4α-pma;4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%;(1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9-myristate 9a-acetate;4α-TPA;4-alpha-Phorbol 12-Myristate 13-Acetate >99%;4-α-Phorbol-12-Myristate-13-acetate / 4-α-12-Tetradecanoyl phorbol-13-acetate;4-alpha-PMA, 4-alpha-TPA | CAS: | 63597-44-4 | MF: | C36H56O8 | MW: | 616.83 | EINECS: | | Product Categories: | metabolite | Mol File: | 63597-44-4.mol | |
| 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Chemical Properties |
storage temp. | -20°C | solubility | H2O: ~2 μM Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media. | form | solid | color | white | Sensitive | Light Sensitive |
| 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Usage And Synthesis |
Uses | 4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes. | Biochem/physiol Actions | Negative control for phorbol ester activation of protein kinase C. |
| 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Preparation Products And Raw materials |
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