毒胡萝卜素
| 中文名称 | 毒胡萝卜素 |
|---|---|
| 中文同义词 | 毒胡萝卜素(>95% (HPLC),BC);毒胡萝卜素, 来源于毒胡萝卜;毒萝卜素;毒胡萝卜素 5MG;化合物TTP 22;(3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-乙酰氧基-4-(丁酰氧基)-3,3A-二羟基-3,6,9-三甲基-8-(((Z)-2-甲基丁-2-烯酰基)氧基)-2-氧代-2,3,3A,4,5,6,6A,7,8,9B-十氢薁并[4,5-B]呋喃-7-基辛酸酯;毒胡萝卜素(10 MM IN DMSO)(进口);毒胡萝卜素(10 MM IN DMSO) |
| 英文名称 | Thapsigargin |
| 英文同义词 | THAPSIGARGIN;Octanoic acid, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]f uran-7-yl ester;(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate;Octanoic acid [(3S)-6α-acetoxy-2,3,3a,4,5,6,6aα,7,8,9bβ-decahydro-3β,3aα-dihydroxy-3,6,9-trimethyl-8β-[[(Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4β-(1-oxobutoxy)azuleno[4,5-b]furan]-7α-yl ester;Thapsigargin,97%;Octanoic Acid (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b- decahydro-3,3a-dihydroxy-3,6,9-triMethyl-8-[[(2Z)-2-Methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl Ester;Octanoic Acid [3S-[3α,3aβ,4α,6β,6aβ,7β,8α(Z),9bα]]-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-triMethyl-8-[(2-Methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl Ester;Thapsigargin (TG) |
| CAS号 | 67526-95-8 |
| 分子式 | C34H50O12 |
| 分子量 | 650.75 |
| EINECS号 | 614-076-3 |
| 相关类别 | 合成;生化试剂;抗生素;化合物;试剂盒-细胞分析试剂盒;标准品;对照品;plantgrowth;Adenosinetriphosphatase (microsomal calcium)Cell Signaling and Neuroscience;Antitumor Agents;Intracellular Calcium RegulatorsCancer Research;Intracellular Calcium Signaling;Therapy Adjuncts;A to;Enzyme Inhibitors by Enzyme;Calcium signaling;Signalling;Apoptosis;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 67526-95-8.mol |
| 结构式 |  |
毒胡萝卜素 性质
| 沸点 | 597.77°C (rough estimate) |
|---|---|
| 密度 | 1.1521 (rough estimate) |
| 折射率 | 1.6390 (estimate) |
| RTECS号 | RH0325700 |
| 储存条件 | -20°C |
| 溶解度 | 可溶于DMSO |
| 形态 | 液体或薄膜态 |
| 酸度系数(pKa) | 10.57±0.70(Predicted) |
| 颜色 | 无色 |
| 敏感性 | Light Sensitive |
| 稳定性 | DMSO或乙醇溶液可在-20°下稳定储存1周。 |
| CAS 数据库 | 67526-95-8(CAS DataBase Reference) |
| Target | Value |
|
SERCA
() |
Thapsigargin (0.001- 1 μM; for 2 and 4 days) arrests cell proliferations in MH7A human rheumatoid arthritis synovial cells in a time- and dose-dependent manner.
Thapsigargin (0.001- 1 μM; for 2 and 4 days) induces cell apoptosis in MH7A cells in a time- and dose-dependent manner.
Thapsigargin (0.001- 1 μM; for 2 and 4 days) impairs mTOR activity and leads to cyclin D1 expressions in MH7A cells.
Thapsigargin inhibits Ca
2+
entry into human neutrophil granulocytes.
Thapsigargin inhibits the carbachol-evoked [Ca
2+
]i-transients with (IC
50
=0.353 nM) or without (IC
50
=0.448 nM) a KCl-prestimulation, but an additional small component, with a much lower sensitivity (IC
50
=4814 nM), is observed in the absence of a KCl-prestimulation. In contrast, the KCl-evoked [Ca
2+
]i-transients displayed only one component with a very low sensitivity to Thapsigargin in both absence (IC
50
=3343 nM) and presence (IC
50
=6858 nM) of a carbachol-prestimulation.
Cell Proliferation Assay
| Cell Line: | MH7A human rheumatoid arthritis synovial cells |
| Concentration: | 0.001, 0.1, and 1 μM |
| Incubation Time: | For 2 and 4 days |
| Result: | Arrested cell proliferations in a time- and dose-dependent manner. |
Apoptosis Analysis
| Cell Line: | MH7A human rheumatoid arthritis synovial cells |
| Concentration: | 0.001, 0.1, and 1 μM |
| Incubation Time: | For 2 and 4 days |
| Result: | Induces cell apoptosis in a time- and dose-dependent manner. |
Western Blot Analysis
| Cell Line: | MH7A human rheumatoid arthritis synovial cells |
| Concentration: | 0.001, 0.1, and 1 μM |
| Incubation Time: | For 2 and 4 days |
| Result: | Impairs mTOR activity and leads to cyclin D1 expressions |
Thapsigargin (Injection; 0.25 ug/g, 0.5 ug/g and 1 ug/g; 24 hours) significant increases of 2 to 5-fold in chemokine and pro-inflammatory expression. Thapsigargin is more sensitive to inducing a systemic immune response.
| Animal Model: | Male Balb/c mice (20-25 g) |
| Dosage: | 0.25 ug/g, 0.5 ug/g and 1 ug/g |
| Administration: | Injection; 24 hours |
| Result: | Increased of 2 to 5-fold in chemokine and pro-inflammatory expression. |
安全信息
| 危险品标志 | Xn,T |
|---|---|
| 危险类别码 | 36/37/38-42 |
| 安全说明 | 26-36/37/39 |
| 危险品运输编号 | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| 海关编码 | 29181990 |
| 提供商 | 语言 |
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英文
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-13433 | 毒胡萝卜素 Thapsigargin | 67526-95-8 | 1mg | 1000元 |
| 2024/01/25 | HY-13433 | 毒胡萝卜素 Thapsigargin | 67526-95-8 | 5mg | 2800元 |