| Company Name: |
Alta Scientific Co., Ltd.
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| Tel: |
022-6537-8550 15522853686 |
| Email: |
sales@altasci.com.cn |
| Products Intro: |
Product Name:Talampicillin hydrochloride
CAS:39878-70-1
Purity:99% Package:10mg;100mg;1g
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| Company Name: |
Hubei Moco Chemical Co., Ltd.
|
| Tel: |
18627756402 |
| Email: |
3001051413@qq.com |
| Products Intro: |
Product Name:Talampicillin Hydrochloride
CAS:39878-70-1
Purity:95% HPLC Package:20mg;50mg;100mg
|
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| | Talampicillin hydrochloride Basic information |
| Product Name: | Talampicillin hydrochloride | | Synonyms: | 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-aminophenylacetyl]amino]-3,3-dimethyl-7-oxo-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester, monohydrochloride, (2S,5R,6R)- (9CI);Ampicillin phthalidyl ester hydrochloride;D-Talampicillin hydrochloride;PC 183;Talat;Talpen;Yamacillin;Ampicillinphthalidyl hydrochloride | | CAS: | 39878-70-1 | | MF: | C24H23N3O6S.ClH | | MW: | 517.988 | | EINECS: | | | Product Categories: | | | Mol File: | 39878-70-1.mol |  |
| | Talampicillin hydrochloride Chemical Properties |
| Melting point | 154-157° (dec) |
| | Talampicillin hydrochloride Usage And Synthesis |
| Description | Talampicillin was synthesized by Yamanouchi Pharmaceutical Co. in 1971 by esterifying the carboxylic acid group of ampicillin in order to improve the oral absorption. When administered orally, it is hydrolyzed to ampicillin by intestinal esterase. Its bioavailability is two or more times as high as that of ampicillin, and it is used to treat the same infections as those for which ampicillin is used orally but in doses only half or one-third as large. | | Originator | Talpen,Beecham,US,1975 | | Manufacturing Process | A fine suspension of 25.18 grams (0.05 mol) of potassium salt of enamine
protected ampicillin and 10.65 grams (0.05 mol) 3-bromophthalide were
reacted in a 1:2 mixture of acetone/ethyl acetate (1,500 ml) for 24 hours.
After filtration the organic layer was washed twice with 250 ml portions of 1 N
sodium bicarbonate and brine, dried over anhydrous magnesium sulfate and
concentrated in vacuo. Addition of ether crystallized the phthalide enamine
protected α-aminophenylacetamido penicillanate in 85% yield. | | Therapeutic Function | Antibacterial |
| | Talampicillin hydrochloride Preparation Products And Raw materials |
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