RENTIAPRIL RACEMATE
中文名称 | RENTIAPRIL RACEMATE |
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中文同义词 | 伦唑普利外消旋体;伦噻普利外消旋体;化合物 T16731 |
英文名称 | rentiapril |
英文同义词 | 2-(2'-Hydroxyphenyl)-3-(3-mercaptopropanoyl)-4-thiazolidine carboxylic acid;4-Thiazolidinecarboxylic acid, 2-(2-hydroxyphenyl)-3-(3-mercapto-1-oxopropyl)-;Rentiapril (racemate);2-(2-hydroxyphenyl)-3-(3-sulfanylpropanoyl)-1,3-thiazolidine-4-carboxylic acid;SA-446 racemate |
CAS号 | 72679-47-1 |
分子式 | C13H15NO4S2 |
分子量 | 313.39 |
EINECS号 | |
相关类别 | |
Mol文件 | 72679-47-1.mol |
结构式 |
RENTIAPRIL RACEMATE 性质
沸点 | 553.7±50.0 °C(Predicted) |
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密度 | 1.451±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 3.02±0.40(Predicted) |
Angiotensin converting enzyme (ACE)
A three-months toxicity study of an angiotensin converting enzyme (ACE) inhibitor, Rentiapril (CAS 80830-42-8), is performed in Sprague-Dawley rats by oral administration. The dose levels of 0, 30, 125, 500 and 1000 mg/kg are tested in both sexes, in which each experimental group comprised 10 rats. Another ACE inhibitor, captopril, is used as a reference compound. Rentiapril at the highest dose of 1000 mg/kg causes low food consumption and death of some animals with signs of bloody feces and anemia. In males and females receiving 500 and 1000 mg/kg, there are low body weight gain, increases in water intake, urine volume and serum BUN level, and decreases in levels of various erythrocytic parameters. Kidney weight is increased dose-dependently in both sexes. Histopathologically, renal changes in the 500 and 1000 mg/kg groups consist of proximal tubular degeneration, juxtaglomerular cell hyperplasia and interstitial cell infiltration. Similar, but mild, changes in proximal tubules are present in the female 125 mg/kg group. Dead animals from the highest dose groups further show gastrointestinal hemorrhagic erosion and/or ulcer, decrease bone marrow erythropoiesis and hepatocytic vacuolar degeneration. There is no pathological alteration in rats from other Rentiapril-treated groups, as well as in controls. These results indicate that the no-effect dose of Rentiapril in rats by three months oral administration is 30 mg/kg in female and 125 mg/kg in male.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-U00074 | RENTIAPRIL RACEMATE Rentiapril racemate | 72679-47-1 | 1 mg | 909元 |
2024/04/30 | HY-U00074 | RENTIAPRIL RACEMATE Rentiapril racemate | 72679-47-1 | 5 mg | 2000元 |