宝藿苷I
| 中文名称 | 宝藿苷I |
|---|---|
| 中文同义词 | 宝藿苷Ⅰ;宝藿苷I,淫羊藿次苷Ⅱ;宝藿苷I;宝藿苷I(标准品);宝霍苷I((淫羊藿次苷II,脱水淫羊藿苷);BAOHUOSIDE I 宝藿苷I;宝藿苷Ⅰ(分析标准品);淫羊藿次苷II 、宝藿苷Ⅰ |
| 英文名称 | baohuoside I |
| 英文同义词 | 3-(α-L-Rhamnopyranosyloxy)-4'-methoxy-5,7-dihydroxy-8-prenylflavone;5,7-Dihydroxy-4'-methoxy-8-prenyl-3-(α-L-rhamnopyranosyloxy)flavone;Baohuoside-1;Icariin II;Icarisid II;BAOHUOSIDE I; ANHYDROICARITIN; ICARISIDE II;Baohuoside I(Icariside II);baohuoside I |
| CAS号 | 113558-15-9 |
| 分子式 | C27 H30 O10 |
| 分子量 | 514.52 |
| EINECS号 | |
| 植物来源 | 淫羊藿 |
| 相关类别 | 中药对照品;标准品;植物提取物;植提标准品;对照品;标准物质;标准品-中药标准品;分析试剂标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;植物药;可定制;黄酮;标准品 -中药标准品;分析试剂-指示剂;标准品，对照品 |
| Mol文件 | 113558-15-9.mol |
| 结构式 |  |
宝藿苷I 性质
| 熔点 | 202-203 °C |
|---|---|
| 沸点 | 759.4±60.0 °C(Predicted) |
| 密度 | 1.46 |
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | 可溶于二甲基亚砜、甲醇 |
| 酸度系数(pKa) | 6.29±0.40(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄色 |
|
CXCR4
|
Baohuoside I is an inhibitor of CXCR4, and downregulates CXCR4 expression at 12-25 μM. Baohuoside I (0-25 μM) suppresses NF-κB activation in a dose-dependent manner, suppresses CXCL12 induced the invasion of cervical cancer cells. Baohuoside I also inhibits invasion of breast cancer cells. Baohuoside I inhibits A549 cell viability, with IC 50 s of 25.1 μM at 24 h, 11.5 μM and 9.6 μM at 48 h and 72 h, respectively. Baohuoside I ((25 μM) suppresses the caspase cascade in A549 cells, elevates ROS levels and activates JNK and p38 MAPK signaling cascade. Baohuoside I (3.125, 6.25, 12.5, 25.0 and 50.0 µg/mL) significantly and dose-dependently blocks the growth of esophageal squamous cell carcinoma Eca109 cells, with an IC 50 of 4.8 µg/mL at 48 h.
Baohuoside I (25 mg/kg) decreases β-catenin protein levels, cyclin D1 and survivin expression in nude mice.
安全信息
| 海关编码 | 29329990 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N0011 | 宝藿苷I Baohuoside I | 113558-15-9 | 5 mg | 800元 |
| 2024/01/25 | HY-N0011 | 宝藿苷I Baohuoside I | 113558-15-9 | 10mg | 1200元 |