地榆皂苷I
中文名称 | 地榆皂苷I |
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中文同义词 | 苦丁冬青苷 H,苦丁冬青甙H,地榆糖苷I;苦丁冬青甙 H;地榆皂苷I;苦丁冬青苷H;地榆皂苷I(标准品);苦丁冬青甙 I;地榆皂苷I(苦丁冬青苷 H,苦丁冬青甙H,地榆糖苷I);地榆糖苷I) |
英文名称 | 3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester |
英文同义词 | 3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester;Kudinoside H;Zigu-glucoside I;Gouguside 7;Ulmus pumila saponin I;Ziyu-glycoside Ⅰ;Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, β-D-glucopyranosyl ester, (3β)-;[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate |
CAS号 | 35286-58-9 |
分子式 | C41H66O13 |
分子量 | 766.95 |
EINECS号 | 233-305-4 |
相关类别 | 对照品;中药对照品;标准品;植物提取物;植提标准品;分析试剂标准品;标准品-中药标准品;标准品-对照品;三萜;标准品 -中药标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品,对照品 |
Mol文件 | 35286-58-9.mol |
结构式 |
地榆皂苷I 性质
熔点 | 198-202 ºC |
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沸点 | 841.9±65.0 °C(Predicted) |
密度 | 1.35 |
储存条件 | -20°C, protect from light |
溶解度 | 溶于乙腈和甲醇; |
形态 | 粉末 |
酸度系数(pKa) | 12.52±0.70(Predicted) |
颜色 | 白色 |
水溶解性 | insoluble in water |
Ziyuglycoside I (5-160 µM; 24 hours) reveals a marked anti-proliferation activity with an IC 50 value of 13.96 µM in MDA-MB-231 cells. Ziyuglycoside I (5-20 µM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 µM. Ziyuglycoside I (5-20 µM; 24 hours) induces the cleavage of caspas-8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression.
Cell Viability Assay
Cell Line: | MDA-MB-231 cells |
Concentration: | 5 µM, 10 µM, 20 µM, 40 µM, 80 µM, and 160 µM |
Incubation Time: | 24 hours |
Result: | Showed cytotoxicity on MDA-MB-231 cells. |
Cell Cycle Analysis
Cell Line: | MDA-MB-231 cells |
Concentration: | 5 µM, 10 µM, and 20 µM |
Incubation Time: | 24 hours |
Result: | Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells |
Western Blot Analysis
Cell Line: | MDA-MB-231 cells |
Concentration: | 5 µM, 10 µM, and 20 µM |
Incubation Time: | 24 hours |
Result: | Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways. |
药理药效:具有一定的保肝利胆效果。