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WHI-P97

WHI-P97 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:WHI-P97
CAS:211555-05-4
Purity:0.99 Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Email: linda@hubeijusheng.com
Products Intro: Product Name:JAK3 Inhibitor I
CAS:211555-05-4
Purity:0.99 Package:5KG;1KG
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674;
Email: laboratory@coreychem.com
Products Intro: Product Name:2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
CAS:211555-05-4
Purity:85.0-99.8% Package:1ASSAYS;1USD
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Products Intro: Product Name:JAK3 Inhibitor I
CAS:211555-05-4
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:WHI-P97
CAS:211555-05-4
Purity:98% Package:5mg Remarks:V3972
WHI-P97 Basic information
Product Name:WHI-P97
Synonyms:WHI-P 974-(3',5'-DibroMo-4-hydroxyphenyl)aMino-6,7-diMethoxyquinazoline;2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol;JAK3 Inhibitor I USP/EP/BP;Phenol, 2,6-dibromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-;WHI-P-97;WHI P97;WHI-P97;Janus kinase,JAK,airway,Inhibitor,WHIP97,eosinophil recruitment,WHI-P97,inhibit,ovalbumin challenge,WHI P97,ovalbumin-sensitized,WHI-P-97
CAS:211555-05-4
MF:C16H13Br2N3O3
MW:455.1
EINECS:
Product Categories:
Mol File:211555-05-4.mol
WHI-P97 Structure
WHI-P97 Chemical Properties
Boiling point 470.9±45.0 °C(Predicted)
density 1.785
storage temp. Store at -20°C
solubility DMSO : 5.88 mg/mL (12.92 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form Powder
pka7.05±0.36(Predicted)
Safety Information
MSDS Information
WHI-P97 Usage And Synthesis
DefinitionChEBI: 2,6-dibromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol is a member of quinazolines.
Biological ActivityWHI-P97 is a potent JAK-3 inhibitor with Ki of 0.09 μM and IC50 of 2.5 μM in EGFR kinase inhibition assay.
in vitro

WHI-P97 inhibits the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcεRI crosslinking by >90 % at low micromolar concentrations. WHI-P97 (30 μM) stantially reduces the IgE/antigen-induced LTC4 release from mast cells.

in vivo

WHI-P97 is very well tolerated in mice, with no signs of toxicity at dose levels ranging from 5 μg/kg to 50 mg/kg, and LD 10 is not reached at a 50 mg/kg dose level when administered as a single ip or iv bolus dose. WHI-P97 (iv injection; 40 mg/kg; single dose) has an elimination half-life (t 1/2 ) of 58.9 min and systemic clearance (CL) of 891 ml/h/kg in CD-1 mice and at 1/2 of 84.2 min and CL of 1513 ml/h/kg in BALB/ c mice. The values for AUC and C max are 107.3 μM and 296.7 μM, respectively, in CD-1 mice. And the IC 50 values are 58.4 μM and 212.7 μM , respectively, in BALB/c mice. The large volume of distribution are 322 ml/kg in CD-1 mice and 415 ml/kg in BALB/c mice. WHI-P97 (intraperitoneal injection; 40 mg/kg; 24 days) prevents ovalbumin-sensitized mice the development of airway hyper-responsiveness to methacholine in a dose-dependent fashion in mice. WHI-P97 inhibits the eosinophil recruitment to the airwa y lumen after the ovalbumin challenge in a dose-dependent fashion.

Animal Model: BALB/c mouse model of allergic asthma
Dosage: 40 mg/kg
Administration: intraperitoneal injection; 24 days
Result: Showed promising biological activity in a mouse model of allergic asthma at nontoxic dose levels.
target
TargetValue
JAK3
()
WHI-P97 Preparation Products And Raw materials
Tag:WHI-P97(211555-05-4) Related Product Information
JAK3 INHIBITOR I 4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL 3'-Hydroxyacetophenone Dihydroxybenzoic acid 2-HYDROXYACETOPHENONE 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE JAK3 Inhibitor Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-