|
|
| Product Name: | Betamethasone 21-phosphate disodium | | Synonyms: | 9a-fluoro-16b-methylprednisolone-21-(disodium phosphate);1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-PHOSPHATE, DISODIUM SALT;Pregna-1,4-Diene-3,20-Dione,9-Fluoro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-,DisodiumSalt,(11Beta,16Beta)-;BETAMETHASONE 21-PHOSPHATE DISODIUM SALT;BETAMETHASONESODIUMPHOSPHATE,USP;Celestan;Disodium betamethasone 21-phosphate;NSC 90616 | | CAS: | 151-73-5 | | MF: | C22H28FNa2O8P | | MW: | 516.4 | | EINECS: | 205-797-0 | | Product Categories: | CELESTONE;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Steroids;Betamethasone;Hormones;Steroid Hormones;151-73-5 | | Mol File: | 151-73-5.mol |  |
| | Betamethasone 21-phosphate disodium Chemical Properties |
| Melting point | 206-211°C | | alpha | +98.0～+104.0°(D/20℃)(c=1,H2O) (calculated on the dehydrous basis) | | storage temp. | room temp | | solubility | Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. | | color | White to Off-White | | PH | 7.5～9.0(5g/l, 25℃) | | Merck | 14,1180 | | Stability: | Hygroscopic | | InChIKey | PLCQGRYPOISRTQ-LWCNAHDDSA-L | | SMILES | [C@@]12([H])C[C@H](C)[C@](O)(C(=O)COP([O-])([O-])=O)[C@@]1(C)C[C@H](O)[C@]1(F)[C@@]3(C)C=CC(=O)C=C3CC[C@@]21[H].[Na+].[Na+] |&1:0,3,5,15,18,20,22,32,r| | | EPA Substance Registry System | .beta.-Methasone disodium phosphate (151-73-5) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | TU4056500 | | HS Code | 29372290 | | Toxicity | LD50 orl-rat: 1877 mg/kg DRUGAY -,1075,90 |
| | Betamethasone 21-phosphate disodium Usage And Synthesis |
| Indications and Usage | Betamethasone Sodium Phosphate, also called Bentelan, Betnesol, betamethasone phosphate, and celestone phosphate, is an adrenal cortex hormone, an isomer of dexamethasone with the same effects as prednisolone and dexamethasone.
It is mainly used against inflammation and allergies. Its effects are the same as those of dexamethasone, and its anti-inflammatory effects are stronger than dexamethasone, prednisone, and cortisone, with fewer side effects. It is used to treat active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, acute leukemia, allergic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, pruritis, and comprehensively treat some infections.
| | Mechanisms of Action | Betamethasone sodium phosphate has pharmacological effects in treating inflammation, rheumatism, allergies, and immunosuppressive conditions. Its anti-inflammatory effects are stronger than those of dexamethasone, triamcinolone, and hydrocortisone. It can reduce and prevent tissue response to inflammation, partly eliminating non-infectious inflammation caused by fever, redness, and swelling, thereby reducing the presence of swelling. The anti-inflammatory effects of 0.3 mg of betamethasone sodium phosphate are comparable to those of 0.75 mg of dexamethasone, 5 mg of prednisone, or 25 mg of cortisone. Its sodium retention effects are more than a hundred times those of cortisone. In case of primary adrenal hypofunction, together with corticosteroids, it can be used to replace treatment or prevention, or inhibit of cellular immune response, delay allergic reaction, and reduce the extension of the primary immune response, suitable for low renin and low aldosterone syndrome and orthodontic hypotension caused by autonomic neuropathy. | | Contraindications | Not for use by those with a history of serious mental illness, active duodenum, gastric ulcers, recent gastrointestinal anastomosis, serious osteoporosis, pronounced diabetes, or serious high blood pressure, viruses which cannot be treated by antibiotics, bacterial of fungal infection, thrombophlebitis, or infectious skin diseases such as impetigo, tinea corporis, or tinea cruris. | | Category | Toxic | | Toxicity level | Medium | | Acute toxicity | Oral administration - mice LD50: >4500 mg/kg | | Flammability | Flammable; produces toxic fluoride fumes | | Storage and transport | Store in a cool, ventilated, and dry place | | Extinguishing agents | Dry powder, foam, sand, carbon dioxide, mist | | Chemical Properties | White or almost white powder, very hygroscopic. | | Uses | Betamethasone 21-Phosphate Disodium Salt (Dexamethasone Sodium Phosphate EP Impurity B) is a Betamethasone derivative. It is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties which can be used in treatment of asthma and itching. | | Uses | An anti-inflammatory agent | | Uses | Nasal, Ophthalmic, Oral, Parenteral | | Uses | antiinflammatory, glucocorticoid | | Definition | ChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate. | | Brand name | Celestone (Schering). | | Biochem/physiol Actions | Betamethasone is used to treat neonatal respiratory distress syndrome, and psoriasis. | | Safety Profile | Moderately toxic by ingestion andother routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F??, POx and Na2O. |
| | Betamethasone 21-phosphate disodium Preparation Products And Raw materials |
|