Ponatinib Hydrochloride

Ponatinib Hydrochloride Suppliers list
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: CAS:1114544-31-8
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Ponatinib Hydrochloride
Purity:95.0-99.8% Package:1KG;1USD|1KG;2USD
Company Name: TianYuan Pharmaceutical CO.,LTD
Tel: +86-755-23284190 13684996853
Email: sales@tianpharm.com
Products Intro: Product Name:Ponatinib hcl
Purity:99% Package:10g 100g 200g 500g 1kg 5kg per barrel
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:Ponatinib Mono-hydrochloride
Purity:98% HPLC LCMS Package:10G;20G
Company Name: Shochem(Shanghai) Co.,Ltd
Tel: 86-21-50800795
Email: info@shochem.com
Products Intro: Product Name:Ponatinib hydrochloride
Purity:0.98 Package:10g, 1kg

Lastest Price from Ponatinib Hydrochloride manufacturers

  • Ponatinib Hydrochloride
  • US $1.00-2.00 / KG
  • 2019-09-03
  • CAS:1114544-31-8
  • Min. Order: 1KG
  • Purity: 95.0-99.8%
  • Supply Ability: 1KG;5KG 10KG; 100KG
  • Ponatinib Hydrochloride
  • US $0.00-0.00 / KG
  • 2019-08-19
  • CAS:1114544-31-8
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50kg/month
Ponatinib Hydrochloride Basic information
Product Name:Ponatinib Hydrochloride
Synonyms:AP24534 Mono-hydrochloride;Ponatinib Mono-hydrochloride;3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride;Ponatinib hydrochloride;Ponatinib-HCl;AP24534-HCl
Product Categories:
Mol File:1114544-31-8.mol
Ponatinib Hydrochloride Structure
Ponatinib Hydrochloride Chemical Properties
Safety Information
MSDS Information
Ponatinib Hydrochloride Usage And Synthesis
DescriptionIn December 2012, the US FDA approved ponatinib (also referred to as AP 24534) for the treatment of adult patients with chronic phase, accelerated phase, or blast phase chronicmyeloid leukemia (CML). Ponatinib is a pan-Bcr–Abl TKI that blocks both the native (IC50=0.4 nM) and Bcr– AblT315I mutated kinases (IC50=2.0 nM) in addition to othermutated kinases in CML patients. In the Ba/F3 cell proliferation assay, ponatinib inhibits ABL and the T315I Abl mutant with IC50s of 1.2 and 8.8 nM, respectively. Ponatinib was identified by a structure-based drug design approach. Ponatinib binds to the kinase domain in a DFG-out conformation; the ethynyl moiety helps the inhibitor evade the mutant gatekeeper isoleucine residue at position 315. In addition to Abl and the T315I mutant of Abl, ponatinib inhibits VEGFR, PDGFR, FGFR, SRC, KIT, RET, TIE2, FLT3, and EPH receptors at concentrations ranging from0.1 to 20 nM.
OriginatorAriad (United States)
Brand nameIclusig
Ponatinib Hydrochloride Preparation Products And Raw materials
Tag:Ponatinib Hydrochloride(1114544-31-8) Related Product Information
Enzalutamide PLERIXAFOR N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide Enasidenib Nintedanib Safinamide mesylate Tofacitinib citrate PI-103 Cabozantinib R428 N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea WZ4002 Regorafenib AP26113 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Niraparib Galeterone Ponatinib