GSK2801
| 中文名称 | GSK2801 |
|---|---|
| 中文同义词 | 1-[1-[2-(甲基磺酰基)苯基]-7-丙氧基-3-吲哚嗪基]乙酮;BAZ2A和BAZ2B抑制剂(GSK2801);1-(1-(2-(甲磺酰)苯基)-7-丙氧基吲哚嗪-3-基)乙酮;化合物GSK2801;GSK2801,BAZ2A和BAZ2B抑制剂 |
| 英文名称 | GSK 2801 |
| 英文同义词 | GSK 2801;GSK2801;GSK-2801;1-(7-(2-Methylsulfonyl-phenyl)-4-propoxy-1-aza-bicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl)-ethanone;1-(1-(2-(methylsulfonyl)phenyl)-7-propoxyindolizin-3-yl)ethanone;1-[1-[2-(Methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]ethanone;Ethanone, 1-[1-[2-(methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]-;GSK-2801; GSK 280 |
| CAS号 | 1619994-68-1 |
| 分子式 | C20H21NO4S |
| 分子量 | 371.45 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;细胞生物学试剂;Inhibitors |
| Mol文件 | 1619994-68-1.mol |
| 结构式 |  |
GSK2801 性质
| 密度 | 1.23±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | -20°C |
| 溶解度 | 不溶于水； DMSO 中≥18.55 mg/mL；温和加热和超声波下，乙醇中≥2.82 mg/mL |
| 形态 | 固体 |
Kd: 136 nM (BAZ2A) and 257 nM (BAZ2B)
GSK2801 binds TAF1L(2) with an affinity K
B
of 0.31μM (K
D
: 3.2 μM) and a binding enthalpy change ΔH of −8.6 kcal/mol. ITC experiments using the bromodomain of BRD9 results in the determination of an affinity K
B
of 0.826 μM (K
D
: 1.1 μM) and ΔH of −9.8 kcal/mol.
GSK2801 or RNAi knockdown of BAZ2A/B with JQ1 selectively displaced BRD2 at promoters/enhancers of ETS-regulated genes. In 2D cultures, enhances displacement of BRD2 from chromatin by combination drug treatment induced senescence. In spheroid cultures, combination treatment induces cleaved caspase-3 and cleaved PARP characteristic of apoptosis in tumor cells. Thus, GSK2801 blocks BRD2-driven transcription in combination with BET inhibitor and induces apoptosis of TNBC.
In order to determine the suitability of GSK2801 for in vivo experiments, pharmacokinetic parameters after intraperitoneal and oral dosing to male CD1 mice is measured. GSK2801 has reasonable in vivo exposure after oral dosing, modest clearance, and reasonable plasma stability.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-15658 | GSK2801 | 1 mg | 260元 | |
| 2024/01/25 | HY-15658 | GSK2801 GSK2801 | 1619994-68-1 | 5mg | 650元 |