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| | (3S,5R)-Rosuvastatin Basic information |
| Product Name: | (3S,5R)-Rosuvastatin | | Synonyms: | (3S,5R)-Rosuvastatin;(3s,5r,6e)-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid;Rosuvastatin EP Impurity G;Rosuvastatin (3S,5R) Enantiomer (as diisopropylamine salt);(3S,5R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid;Rosuvastatin (3S,5R) enantiomer;(3S,5R,6E)-Rosuvastatin;(3S,5R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid, calcium salt (2:1) | | CAS: | 1242184-42-4 | | MF: | C22H28FN3O6S | | MW: | 481.54 | | EINECS: | | | Product Categories: | | | Mol File: | 1242184-42-4.mol |  |
| | (3S,5R)-Rosuvastatin Chemical Properties |
| Boiling point | 745.6±70.0 °C(Predicted) | | density | 1.368±0.06 g/cm3(Predicted) | | solubility | soluble in Methanol, Water | | pka | 4.25±0.10(Predicted) | | form | Solid | | color | Off-White to Pale Yellow | | Stability: | Hygroscopic |
| | (3S,5R)-Rosuvastatin Usage And Synthesis |
| Description | Rosuvastatin is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. | | Uses | (3S,5R,6E)-Rosuvastatin is an isomer of Rosuvastatin(R700500), an impurity which acts as a selective, competitive HMG-CoA reductase inhibitor. | | Biological Activity | (3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels. |
| | (3S,5R)-Rosuvastatin Preparation Products And Raw materials |
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