AZD 3759

AZD 3759 Suppliers list
Company Name: Nanjing Gold Pharmaceutical Technology Co. Ltd.
Tel: 025-84209270 15906146951
Email: wgp@nanjing-pharmaceutical.com
Products Intro: Product Name:AZD3759
CAS:1626387-80-1
Purity:99% Package:1000KG;;100KG;10KG;5KG;1KG
Company Name: Jurong Coupling Biotechnology Co., Ltd.
Tel: 13656108824
Email: coupling278191416@hotmail.com
Products Intro: Product Name:AZD 3759
CAS:1626387-80-1
Purity:99% HPLC Package:5KG;1KG
Company Name: Shanghai Payne Pharmaceutical Technology Co.Ltd
Tel: 021-58123769
Email: info@paynepharm.com
Products Intro: Product Name:AZD 3759
CAS:1626387-80-1
Purity:0.99 Package:5KG;1KG
Company Name: Handan Tongyi New Material Technology Co., Ltd
Tel: +8617330042575;19831061835;18132658905;18831023207
Email: ty003@handantongyi.com
Products Intro: Product Name:AZD 3759
CAS:1626387-80-1
Purity:99.9% Package:1ASSAYS;100USD
Company Name: Hebei Yirun Sega Biological Technology Co. Ltd
Tel: +8619932103556
Email: linda@yrsjbiotech.com
Products Intro: Product Name:AZD3759
CAS:1626387-80-1
Purity:99% Package:20KG;0USD

Lastest Price from AZD 3759 manufacturers

  • AZD 3759
  • US $100.00 / ASSAYS
  • 2021-09-26
  • CAS:1626387-80-1
  • Min. Order: 1ASSAYS
  • Purity: 99.9%
  • Supply Ability: 800kgs/month
  • AZD3759
  • US $10.00 / KG
  • 2021-09-07
  • CAS:1626387-80-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 20 tons
  • AZD3759 Powder
  • US $50.00 / g
  • 2021-09-07
  • CAS:1626387-80-1
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 10000 kg

Related articles

AZD 3759 Basic information
Selective EGFR inhibitor
Product Name:AZD 3759
Synonyms:AZD 3759;AZD3759;AZD-3759;(2R)-2,4-Dimethyl-1-piperazinecarboxylic acid 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester;HY-18750;azd3579;1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester, (2R)-;1-PIPERAZINECARBOXYLIC ACID, 2,4-DIMETHYL-, 4-[(3-CHLORO-2-FLUOROPHENYL)AMINO]-7-METHOXY-6-QUINAZOLINYL ESTER
CAS:1626387-80-1
MF:C22H23ClFN5O3
MW:459.9
EINECS:1592732-453-0
Product Categories:API
Mol File:1626387-80-1.mol
AZD 3759 Structure
AZD 3759 Chemical Properties
Boiling point 571.4±50.0 °C(Predicted)
density 1.358±0.06 g/cm3(Predicted)
pka6.71±0.40(Predicted)
Safety Information
MSDS Information
AZD 3759 Usage And Synthesis
Selective EGFR inhibitor

AZD3759 is a selective EGFR inhibitor that can fully penetrate the blood-brain barrier (BBB), with equal free concentrations in the blood, cerebrospinal fluid, and brain tissue. Treatment with AZD3759 causes tumor regression in subcutaneous xenograft, leptomeningeal metastasis (LM), and brain metastasis (BM) lung cancer models and prevents the development of BM in nude mice.

DescriptionAZD3759 is an EGFP inhibitor (Epidermal growth factor receptor tyrosine kinase inhibitor) with blood brain barrier (BBB) penetration. It has the potential for the treatment of non-small cell lung cancer (NSCLC), with brain metastases (BM) and leptomengingeal metastases (LM) since this type of cancer often contain a lot of activating mutations of the epidermal growth factor receptor (EGFR). It has excellent capability of penetrating the blood brain barrier to reach the central nervous system. 
ReferencesZeng, Qingbei, et al. "Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR TKI)." Journal of Medicinal Chemistry 58.20(2015):8200.
Yang, Zhenfan, et al. "Abstract LB-217: Antitumor activities of AZD3759, a novel EGFR inhibitor with excellent penetration across central nervous system (CNS), in preclinical animal models." Cancer Research 76.14 Supplement(2016):LB-217-LB-217.
Xiong, S., et al. "Determination of AZD3759 in rat plasma and brain tissue by LC-MS/MS and its application in pharmacokinetic and brain distribution studies." Journal of Pharmaceutical & Biomedical Analysis140(2017):362-366.
AZD 3759 Preparation Products And Raw materials
Tag:AZD 3759(1626387-80-1) Related Product Information
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