1361504-77-9
| 中文名称 | 1361504-77-9 |
|---|---|
| 中文同义词 | 化合物DG172 (DIHYDROCHLORIDE);(Z)-2-(2-溴苯基)-3-(4-(4-甲基哌嗪-1-基)苯基)丙烯腈二盐酸盐;DG 172 2HCL,PPARΒ/Δ反向激动剂 |
| 英文名称 | DG172 (dihydrochloride) |
| 英文同义词 | DG172 (dihydrochloride);DG-172 (hydrochloride);DG172 2HCl;DG-172;(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride;(Z)-2-(2-Bromophenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)acrylonitrile dihydrochloride;DG-172,DG172,DG172 dihydrochloride,PPAR,inhibit,DG 172,Inhibitor,Peroxisome proliferator-activated receptors;(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitriledihydrochloride |
| CAS号 | 1361504-77-9 |
| 分子式 | C20H21BrClN3 |
| 分子量 | 418.76 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1361504-77-9.mol |
| 结构式 |  |
1361504-77-9 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 乙醇中≤20mg/ml；DMSO 中≤25mg/ml；二甲基甲酰胺中≤25mg/ml |
| 形态 | 结晶固体 |
|
PPARβ/δ 27 nM (IC 50 ) |
DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC 50 of 27 nM. DG172 enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC 50 , 9.5 nM). DG172 (1 µM) promotes the differentiation of dendritic cells (DCs) from GM-CSF-induced mouse bone marrow cells (BMCs) and reduces Ly6b + /Gr1 + granulocytic cells. DG172 has effects on the transcriptome of GM-CSF differentiated BMCs from WT and Ppard null mice, and acts at a specific stage of GM-CSF-induced differentiation. DG172 (0.1, 1.0 µM) dose-dependently promotes proliferation of TM4 cells. DG172 reduces expression of claudin-11 in TM4 cells.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-19737A | 1361504-77-9 DG172 dihydrochloride | 1361504-77-9 | 5mg | 700元 |
| 2024/01/25 | HY-19737A | 1361504-77-9 DG172 dihydrochloride | 1361504-77-9 | 10mM * 1mLin Water | 770元 |