866927-10-8
| 中文名称 | 866927-10-8 |
|---|---|
| 中文同义词 | 化合物IC87201;2-(((1H-苯并[D][1,2,3]三唑-6-基)氨基)甲基)-4,6-二氯苯酚 |
| 英文名称 | IC87201 |
| 英文同义词 | IC87201;IC87201 >=98% (HPLC);Phenol, 2-[(1H-benzotriazol-6-ylamino)methyl]-4,6-dichloro-;IC-87201 (IC87201;2-[(1H-Benzotriazol-6-ylamino)methyl]-4,6-dichlorophenol;2-(((1H-Benzo[d][1,2,3]triazol-6-yl)amino)methyl)-4,6-dichlorophenol;IC 87201,IC87201,IC-87201,inhibit,iGluR,Inhibitor,Ionotropic glutamate receptors |
| CAS号 | 866927-10-8 |
| 分子式 | C13H10Cl2N4O |
| 分子量 | 309.15 |
| EINECS号 | |
| 相关类别 | API |
| Mol文件 | 866927-10-8.mol |
| 结构式 |  |
866927-10-8 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMF:30.0(最大浓度 mg/mL);97.04(最大浓度 mM) DMSO:29.0(最大浓度 mg/mL);93.81(最大浓度 mM) DMSO:PBS ( pH 7.2) (1:3):0.25(最大浓度 mg/mL);0.81(最大浓度 mM) 乙醇:1.0(最大浓度 mg/mL);3.23(最大浓度 mM) |
| 形态 | 固体 |
IC87201 (500-1800 μM) does not inhibit any of the probe-PDZ interactions involving PDZ1, PDZ2, PDZ3 of PSD-95 or nNOS-PDZ, or bind the canonical PDZ ligand binding sites. IC87201 binds to the β-finger of nNOS-PDZ and allosterically inhibits the nNOS-PDZ/PSD-95-PDZ interactions. IC87201 shows high degree of fluorescence-based artefactual signal when using TAMRA-nNOS as probe. IC87201 (20 μM) suppresses NMDA-stimulated cGMP formation relative to vehicle, in cultured hippocampal neurons. IC87201 (10 and 100 nM) attenuats NMDA/glycine-induced decreases in neurite outgrowth. IC87201 dose-dependently reduces NMDA-induced cGMP production in primary hippocampal neurons (DIV 14-21) with an IC 50 of 2.7 μM. IC87201 increases the number of branches at 10-30 μM when compared to control-treated neurons.
IC87201 (1, 4 and 10 mg/kg, i.p.) does not produce impairment in either spatial working memory or source memory. IC87201 (1 mg/kg) is effective in treating NMDA-induced thermal hyperalgesia in mice, with a corresponding peak plasma level of 55 ng/mL (or 0.2 μM).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-100457 | IC87201 | 5 mg | 812元 | |
| 2024/01/25 | HY-100457 | 866927-10-8 IC87201 | 866927-10-8 | 10mg | 1300元 |