136941-70-3
| 中文名称 | 136941-70-3 |
|---|---|
| 中文同义词 | 化合物 T10101;钙离子通道调节剂1 |
| 英文名称 | 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide |
| 英文同义词 | 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide;Calcium channel-modulator-1;3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-[3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl] 5-methyl ester;Calcium channelmodulator1,Calcium channel modulator 1 |
| CAS号 | 136941-70-3 |
| 分子式 | C26H24Cl2N2O7S |
| 分子量 | 579.44896 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 136941-70-3.mol |
| 结构式 |  |
136941-70-3 性质
| 沸点 | 721.2±70.0 °C(Predicted) |
|---|---|
| 密度 | 1.427±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 2.62±0.70(Predicted) |
Calcium channel-modulator-1是钙离子通道 (calcium channel) 调节剂，阻塞主动脉收缩的 IC50 值为0.8 μM。
IC50: 0.8 μM (Aortic contraction)
Oral administration of Calcium channel-modulator-1 (20 mg/kg) causes a 35-37% decrease in systolic blood pressure in spontaneously hypertensive rats. However, iv administration of Calcium channel-modulator-1 to anesthetized spontaneously hypertensive rats causes a decrease in blood pressure which was more pronounced and long-lasting than that of nifedipine.