拉诺康唑
中文名称 | 拉诺康唑 |
---|---|
中文同义词 | 2-[4-(2-氯苯基)-1,3-二硫戊环-2-亚基]-2-咪唑-1-基-乙腈;[4-(2-氯苯基)-1,3-亚二硫戊环-2-基]-2-咪唑-1-基-乙腈;拉诺康唑;兰诺康唑;(±)-(E)-Α-[4-(2-氯苯基)-1,3-二硫戊烷-2-亚基]-1H-咪唑-1-乙腈 |
英文名称 | Lanoconazole |
英文同义词 | LANOCONAZOLE;[4-(2-chloro-phenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-yl-acetonitrile;(+-)-(e)-(4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene)-1-imidazolylacetonitri;(e)-alpha-(4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene)-1h-imidazole-1-aceton;1h-imidazole-1-acetonitrile,alpha-(4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene);(E)-alpha-(4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene)-1H-imidazole-1-acetonitrile;1H-Imidazole-1-acetonitrile, alpha-(4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene)-, (E)-(+-);(E)-2-[4-(2-Chlorophenyl)-1,3-dithiolane-2-ylidene]-2-(1-imidazolyl)acetonitrile |
CAS号 | 101530-10-3 |
分子式 | C14H10ClN3S2 |
分子量 | 319.83 |
EINECS号 | 635-180-5 |
相关类别 | 抗病源性微生物药;抗真菌感染药物;药物;抗菌药;医药原料;Intermediates & Fine Chemicals;Pharmaceuticals;原料 |
Mol文件 | 101530-10-3.mol |
结构式 |
拉诺康唑 性质
熔点 | 141.50C |
---|---|
沸点 | 477.6±55.0 °C(Predicted) |
密度 | 1.43±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | 可溶于氯仿(少许)、甲醇(少许) |
形态 | 固体 |
酸度系数(pKa) | 3.76±0.10(Predicted) |
颜色 | 白色 |
CAS 数据库 | 101530-10-3(CAS DataBase Reference) |
IC50: antifungal
Lanoconazole (treatment for ear; 0.3%-3%; 6 days) dose‐dependently suppressesTPA-induced irritant dermatitis, suppresses the production of neutrophil chemotactic factors such as keratinocyte‐derived chemokine and macrophage inflammatory protein‐2, and inhibited neutrophil infiltration to the inflammation site.Lanoconazole (oral administration; 3, 10 or 30 mg/kg; once a day; 3 weeks) significantly inhibits C. neoformans compared with the saline control in normal mice. In addtion, it significantly reduces the growth of C. neoformans in the lungs and brains of MAIDS mice.
Animal Model: | BALB/c mice |
Dosage: | 0.3%-3% dosage |
Administration: | Treatment for ear |
Result: | Exhibited an inhibition effect of LCZ on ear swelling induced by topical application of TPA in mice. |
Animal Model: | Four week old C57BL/6 mice infected intraperitoneally with LP-BM5 murine leukaemia virus |
Dosage: | 3, 10 or 30 mg/kg |
Administration: | Oral adminstration |
Result: | Inhibited C. neoformans growth in both normal and C. neoformans -induced encephalitis MAIDS mice . |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-14282 | 拉诺康唑 Lanoconazole | 101530-10-3 | 5mg | 500元 |
2024/08/19 | HY-14282 | 拉诺康唑 Lanoconazole | 101530-10-3 | 10mM * 1mLin DMSO | 550元 |