CS-2692
| 中文名称 | CS-2692 |
|---|---|
| 中文同义词 | 化合物 T12865;化合物SCH-23390 MALEATE |
| 英文名称 | R(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE |
| 英文同义词 | 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-, hydrochloride, (5R)-;8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol, hydrochloride, (R);R-(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HCL;R(+)-SCH-23390 HYDROCHLORIDE;SCH 23390;SCH23390HCl;(R)-8-chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol;CS-2692 |
| CAS号 | 87134-87-0 |
| 分子式 | C17H19Cl2NO |
| 分子量 | 324.24 |
| EINECS号 | |
| 相关类别 | Dopamine receptor |
| Mol文件 | 87134-87-0.mol |
| 结构式 |  |
CS-2692 性质
| 溶解度 | H2O:≥5 mg/mL |
|---|---|
| 形态 | 固体 |
| 颜色 | 白色 |
|
D 1 Receptor 0.2 nM (Ki) |
D 5 Receptor 0.3 nM (Ki) |
5-HT 2C Receptor 9.3 nM (Ki) |
GIRK 268 nM (IC 50 ) |
SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway.
SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants: pilocarpine and soman. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D
1
receptors in rodents, nonhuman primates, and humans.
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat.
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O
2
conditions.
安全信息
| WGK Germany | 3 |
|---|
| 提供商 | 语言 |
|---|---|
|
英文
|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2021/03/30 | S2834 | CS-2692 SCH-23390 maleate | 87134-87-0 | 25mg | 7199.01元 |