1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID
| 中文名称 | 1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID |
|---|---|
| 中文同义词 | |
| 英文名称 | 1,3-dihydro-1-hydroxy-2,1-Benzoxaborole-7-propanoic acid |
| 英文同义词 | 1,3-dihydro-1-hydroxy-2,1-Benzoxaborole-7-propanoic acid;3-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yl)propanoic acid;3-(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-7-yl)propanoic acid;AN3661;AN3661,AN-3661;2,1-Benzoxaborole-7-propanoic acid, 1,3-dihydro-1-hydroxy- |
| CAS号 | 1268335-33-6 |
| 分子式 | C10H11BO4 |
| 分子量 | 206 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1268335-33-6.mol |
| 结构式 |  |
1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID 性质
| 熔点 | 150-151 °C |
|---|---|
| 沸点 | 402.7±55.0 °C(Predicted) |
| 密度 | 1.31±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：250 mg/mL（1213.59 mM） |
| 酸度系数(pKa) | 4.52±0.10(Predicted) |
AN3661 is active at nanomolar (IC
50
=20-56 nM) concentrations against
P. falciparum
laboratory strains known to be sensitive (3D7) or resistant (W2, Dd2, K1, HB3, FCR3 and TM90C2B), and AN3661 is similarly active in ex vivo studies of fresh Ugandan field isolates (mean ex vivo IC
50
=64 nM). AN3661 shows minimal cytotoxicity against mammalian cell lines, with the CC
50
60.5 μM against Jurkat cells, and all other CC
50
values greater than the highest concentrations tested (25 μM or above).
AN3661 inhibits the stability of
P. falciparum
transcripts.
AN3661 (50-200 mg.kg; p.o.; daily for 4 days) inhibits murine
P. berghei
infections with ED
90
(4 days) 0.34 mg/kg.
AN3661 is administered orally for 4 days, beginning on the third day of infection, the ED
90
4 days after initiation of treatment is 0.57 mg/kg.
| Animal Model: | P. berghei -infected mice (malaria model) |
| Dosage: | 50, 100, 200 mg/kg |
| Administration: | Orally; daily for 4 days |
| Result: | Rapidly controlled parasitemias, with an ED 90 of 0.34 mg/kg. Daily dosages of 50 mg/kg and 100 mg/kg extended survival, and mice treated with 200 mg/kg per day demonstrated long-term cures. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-128204 | 1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID AN3661 | 1268335-33-6 | 5mg | 1600元 |
| 2024/01/25 | HY-128204 | 1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID AN3661 | 1268335-33-6 | 10mM * 1mLin DMSO | 1760元 |