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Acebutolol

Acebutolol Suppliers list
Company Name: Mainchem Co., Ltd.
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Products Intro: Product Name:Acebutolol
CAS:37517-30-9
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Products Intro: Product Name:Acebutolol Discontinued. See: A123800
CAS:37517-30-9
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Products Intro: Product Name:Acebutolol
CAS:37517-30-9
Purity:Typically NLT 98%
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Products Intro: Product Name:N-(3-acetyl-4-(2-hydroxy-3-(isopropylaMino)propoxy)phenyl)butyraMide
CAS:37517-30-9
Purity:97% Package:1g;5g;25g;100g;250g;1kg;5kg;10kg;25kg Remarks:we offer low price custom synthesis and contract manufacturing
Acebutolol Basic information
Product Name:Acebutolol
Synonyms:(.+/-.)-3'-Acetyl-4'-[2-hydroxy-3-(1-methylethylamino)propoxy]butyranilide;(.+/-.)-3'-Acetyl-4'-[2-hydroxy-3-(isopropylamino)propoxy]butyranilide;(.+/-.)-N-(3-Acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)butanamide;1-(2-Acetyl-4-n-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane;3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide;5'-Butyramido-2'-(2-hydroxy-3-isopropylaminopropoxy)acetophenone;Butanamide, N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-, (.+/-.)-;dl-Acebutolol
CAS:37517-30-9
MF:C18H28N2O4
MW:336.43
EINECS:253-539-0
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Adrenoceptor
Mol File:37517-30-9.mol
Acebutolol Structure
Acebutolol Chemical Properties
Melting point 119-123°C
Boiling point 472.9°C (rough estimate)
density 1.1748 (rough estimate)
refractive index 1.5700 (estimate)
storage temp. -20°C Freezer
pkapKa 9.40 (Uncertain)
Water Solubility 259 mg/L
CAS DataBase Reference37517-30-9(CAS DataBase Reference)
NIST Chemistry ReferenceAcebutolol(37517-30-9)
Safety Information
Acebutolol Usage And Synthesis
Chemical PropertiesCrystalline Solid
UsesCardioselective ?adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II)
UsesCardioselective β-adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
DefinitionChEBI: An ether that is the 2-acetyl-4-(butanoylamino)phenyl ether of the primary hydroxy group of 3-(propan-2-ylamino)propane-1,2-diol.
Brand nameSectral (Dr. Reddy’s).
General DescriptionAcebutolol is one of the very few β-blockers whosemetabolite plays a significant role in its pharmacological actions.This drug is absorbed well from the gastrointestinaltract, but it undergoes extensive first-pass metabolic conversionto diacetolol by hydrolytic conversion of the amidegroup to the amine, followed by acetylation of the amine. After oral administration, plasma levels of diacetololare higher than those of acebutolol. Diacetolol is also aselective β1-blocker with partial agonistic activity; it has littlemembrane-stabilizing activity. It has a longer half-life (8–12hours) than the parent drug and is excreted by the kidneys.
Clinical UseAcebutolol (Sectral) is a cardioselective 1-adrenoceptor blocking agent that also has some minor membrane stabilizing effects on the action potential. Acebutolol is effective in the management of the patient with essential hypertension, angina pectoris, and ventricular arrhythmias. Antiarrhythmic effects are observed with the patient both at rest and taking exercise.
Side effectsAdverse effects include bradycardia, gastrointestinal upset, dizziness, and headache.
Enzyme inhibitorThis lipophilic, cardioselective b-adrenergic blocker (FW= 336.43 g/mol; CAS Reg. Nos 37517-30-9 and 34381-68-5 (HCl), also known as Sectral? and named systematically as (RS) -N-{3-acetyl-4-[2-hydroxy-3- (propan-2-ylamino) -propoxy]phenyl}butanamide, displays intrinsic sympathomimetic activity (ISA) and is used to treat hypertension and angina. Acebutolol is metabolized to diacetolol, which is as active as acebutolol and shows a same pharmacologic profile. Target (s) : b- adrenergic receptor.
MetabolismAbout half of an orally administered dose of acebutolol (Sectral) is absorbed. Approximately 25% of the drug is bound to plasma proteins, and its plasma halflife is about 4 hours.Metabolism of acebutolol produces a metabolite with -blocking activity whose half-life is 10 hours.
PrecautionsAcebutolol should not be administered in cardiogenic shock, uncontrolled heart failure, or severe bradycardia or to patients with known hypersensitivity to the drug.
Acebutolol Preparation Products And Raw materials
Raw materialsAcetophenone-->Butyramide-->D/L-AMPHETAMINE HYDROCHLORIDE
Tag:Acebutolol(37517-30-9) Related Product Information
4-Methoxyphenylacetone 3-Chloropropyltrimethoxysilane Phenylhydrazine N-ACETYL-L-TYROSINE ETHYL ESTER ACEBUTOLOL HYDROCHLORIDE, EP STANDARD,ACEBUTOLOL HYDROCHLORIDE, IMPURITY CN-(3-ACETYL-4-HYDROXYPHENYL)BUTANAMIDE EP STANDARD,ACEBUTOLOL HYDROCHLORIDE, MM(CRM STANDARD),ACEBUTOLOL HYDROCHLORIDE, IMPURITY IN-[3-ACETYL-4-[(2RS)-3-(ETHYLAMINO)-2-HYDROXYPROPOXY]PHENYL)BUTANAMIDE EP STANDARD,ACEBUTOLOL HYDROCHLORIDE, USP STANDARD,ACEBUTOLOL HYDROCHLORIDE,ACEBUTOLOL HCL Propranolol hydrochloride Atenolol Trimethoxypropylsilane Bisoprolol Propanolol 3-(Trimethoxysilyl)-1-propanamine Trimethoxysilylpropanethiol Diphenyldiethoxysilane PHENYL VALERATE Acetyl chloride Metoprolol Acetylacetone Metoprolol tartrate