Sparstolonin B
| 中文名称 | Sparstolonin B |
|---|---|
| 中文同义词 | 三棱内酯B |
| 英文名称 | Sparstolonin B |
| 英文同义词 | Sparstolonin B;3H-Pyrano[3,4,5-kl]xanthen-3-one, 4,10-dihydroxy-;Sparstolonin B >=98% (HPLC);Sparstolonin B (SsnB) |
| CAS号 | 1259330-61-4 |
| 分子式 | C15H8O5 |
| 分子量 | 268.22 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1259330-61-4.mol |
| 结构式 |  |
Sparstolonin B 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | DMSO：10 mg/mL（需要超声波和加热） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
Sparstolonin B 作为选择性 TLR2 和 TLR4 拮抗剂，选择性阻断 TLR2 和 TLR4 介导的炎症信号传导。Sparstolonin B 具有抗 HIV 和抗癌活性。
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TLR2
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TLR4
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HIV-1
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Sparstolonin B (1-20 µM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells.
Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2.
Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells.
Cell Viability Assay
| Cell Line: | SH-SY5Y, IMR-32, NGP, SKNF-1 and SK-N-BE(2) cells |
| Concentration: | 1 µM, 5 µM, 10 µM or 20 µM |
| Incubation Time: | 2-4 days |
| Result: | Effectively and dose-dependently inhibits the viability of all neuroblastoma cell lines after 2 days (SH-SY5Y and IMR-32), 3 days (NGP cells) or 4 days (SKNF-1 and SK-N-BE(2) cells) treatment. |
Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice.
| Animal Model: | 5-6-week-old male C57Bl/6 mice (body weight 18-20 g) |
| Dosage: | 100 μg/mouse |
| Administration: | I.p. |
| Result: | Significantly lower TNFα and IL-1β expression levels in LPS-induced sepsis mouse model. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-116213 | Sparstolonin B | 1 mg | 954元 | |
| 2024/01/25 | HY-116213 | Sparstolonin B Sparstolonin B | 1259330-61-4 | 5mg | 2100元 |