CINPA1
| 中文名称 | CINPA1 |
|---|---|
| 中文同义词 | 化合物 T14969;化合物CINPA1;CINPA 1,CAR拮抗剂 |
| 英文名称 | CINPA 1 |
| 英文同义词 | Carbamic acid, [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester (9CI);CINPA 1;Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate;Carbamic acid, N-[5-[2-(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester |
| CAS号 | 102636-74-8 |
| 分子式 | C23H29N3O3 |
| 分子量 | 395.49 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 102636-74-8.mol |
| 结构式 |  |
CINPA1 性质
| 沸点 | 545.8±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.179±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：100mM；乙醇：100 mM |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 13.44±0.20(Predicted) |
IC50: ~70 nM (CAR)
CINPA1 (1μM ; 24 hours) inhibits CAR-mediated transactivation without activating PXR in HepG2 cells.
CINPA1 is a specific xenobiotic receptor inhibitor and has no cytotoxic effects up to 30 μM.
CINPA1 inhibits CAR-mediated gene expression in primary human hepatocytes, where CAR is endogenously expressed.
CINPA1 does not alter the protein levels or subcellular localization of CAR.
CINPA1 increases corepressor and reduces coactivator interaction with the CAR ligand-binding domain in mammalian two-hybrid assays.
CINPA1 disrupts CAR binding to the promoter regions of target genes in chromatin immunoprecipitation assays.
CINPA1 efficiently inhibits CAR-LBD interaction with the coactivator peptide that suggesting that CINPA1 is a ligand of CAR.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-110249 | CINPA1 | 1 mg | 304元 | |
| 2024/04/30 | HY-110249 | CINPA1 CINPA1 | 102636-74-8 | 10mM * 1mLin DMSO | 1320元 |