MM 07
| 中文名称 | MM 07 |
|---|---|
| 中文同义词 | APELIN受体多肽;激动剂多肽MM 07;MM 07 三氟乙酸盐;MM 07 TFA |
| 英文名称 | MM 07 |
| 英文同义词 | MM 07;CRPRLCHKGPMPF(Modification: Disulfide bridge: 1-6);MM 07 TFA |
| CAS号 | 1876450-21-3 |
| 分子式 | C67H106N22O14S3 |
| 分子量 | 1539.91 |
| EINECS号 | |
| 相关类别 | 目录肽 |
| Mol文件 | 1876450-21-3.mol |
| 结构式 |  |
MM 07 性质
| 密度 | 1.52±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20° C |
| 酸度系数(pKa) | 3.56±0.10(Predicted) |
| 水溶解性 | Souble in water |
KD: 300 nM (apelin receptor in CHO-K1 cells), 172 nM (apelin receptor in human heart).
MM 07 competes with nanomolar affinities for binding of [Glp 65 ,Nle 75 ,Tyr 77 ] [ 125 I]apelin-13 to human apelin receptors in CHO-K1 cells (K D , 300 nM) and human heart (K D , 172 nM, n=3).
MM 07 causes a dose-dependent increase in cardiac output, and although there is a decrease in vascular resistance, this is without corresponding effects on BP. Administration of SNAP produces a profound fall in BP in both [Pyr 1 ]apelin-13 and MM 07-treated groups; however, although cardiac output is significantly increased in response to SNAP in the MM 07 group, it is significantly reduced in the [Pyr 1 ]apelin-13 group. Neither peptide causes a significant change in heart rate, respiratory rate, or temperature. Both [Pyr 1 ]apelin 13 and MM 07 increases peak velocity above basal levels.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-108003 | 1876450-21-3 MM 07 | 1876450-21-3 | 1mg | 1900元 |
| 2024/01/25 | HY-108003 | 1876450-21-3 MM 07 | 1876450-21-3 | 5mg | 4900元 |