2133364-01-7
中文名称 | 2133364-01-7 |
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中文同义词 | 维格列汀二水合物;维达列汀二水合物;化合物 VILDAGLIPTIN DIHYDRATE |
英文名称 | Vildagliptin dihydrate |
英文同义词 | Vildagliptin dihydrate |
CAS号 | 2133364-01-7 |
分子式 | C17H27N3O3 |
分子量 | 321.42 |
EINECS号 | |
相关类别 | |
Mol文件 | 2133364-01-7.mol |
结构式 |
2133364-01-7 性质
储存条件 | Store at -20°C |
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溶解度 | 溶于二甲基亚砜 |
IC50: 3.5 nM (DPP-IV, in human Caco-2 cells)
Vildagliptin promotes beta cell survival by inhibiting cell apoptosis. Vildagliptin also promotes cell proliferation.
Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice.
Vildagliptin (10 µmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats.
Animal Model: | Male db/db mice (BKS) and wildtype mice |
Dosage: | 35 mg/kg |
Administration: | Oral gavage; once daily; for 6 weeks |
Result: | Increased plasma active GLP-1 levels (22.63±1.19 vs. 11.69±0.44). |
Animal Model: | Obese male Zucker rats |
Dosage: | 10 µmol/kg (Pharmacokinetic Analysis) |
Administration: | Orally |
Result: | Significantly decreased glucose excursions and stimulate insulin secretion. |