|
|
| | PORPHOBILINOGEN Basic information |
| | PORPHOBILINOGEN Chemical Properties |
| Melting point | 174-177℃ | | Boiling point | 479℃ | | density | 1.421 | | Fp | 243℃ | | storage temp. | -20°C | | solubility | Aqueous Base (Slightly), Acetonitrile (Slightly), DMSO (Slightly) | | form | powder | | pka | 4.22±0.10(Predicted) | | color | light yellow to pink | | Merck | 13,7681 | | BRN | 220051 | | EPA Substance Registry System | Porphobilinogen (487-90-1) |
| | PORPHOBILINOGEN Usage And Synthesis |
| Uses | An intermediate in the biosynthesis of Heme, found in the urine of patients with acute porphyria. | | Definition | ChEBI: Porphobilinogen is a dicarboxylic acid that is pyrole bearing aminomethyl, carboxymethyl and 2-carboxyethyl substituents at positions 2, 3 and 4 respectively. It has a role as a metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a member of pyrroles, a dicarboxylic acid and an aralkylamino compound. It is a conjugate acid of a porphobilinogen(1-). | | Biochem/physiol Actions | Intermediate in the biosynthesis of heme. | | Purification Methods | Porphobilinogen recrystallises as the monohydrate (pink crystals) from dilute NH4 OAc solutions of pH 4, and is dried in vacuo. The hydrochloride monohydrate has m 165-170o(dec) (from dilute HCl). [Jackson & MacDonald Can J Chem 35 715 1957, Westall Nature 170 614 1952, Bogarad J Am Chem Soc 75 3610 1953, Beilstein 22/14 V 210.] |
| | PORPHOBILINOGEN Preparation Products And Raw materials |
|