中文名称 | SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE |
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中文同义词 | |
英文名称 | SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE |
英文同义词 | ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, SP-ISOMER TRIETHYLAMMONIUM SALT;ADENOSINE 3',5'-CYCLIC PHOSPHOROTHIOATE-SP, TRIETHYLAMMONIUM SALT;(R)-Adenosine;Cyclic3',5'-(hydrogenphosphorothioate)triethylammonium;(R)-Adenosine,cyclic3',5'-(hydrogenphosphorothioate)triethylammonium;Rp-Adenosine 3′,5′-cyclic Monophosphorothioate, Sodium Salt;adenosine-3’,5’-cyclicmonophosphorothioate,rp-isomer(rp-camps),sodiumsalt;SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE |
CAS号 | 73208-40-9 |
分子式 | C16H27N6O5PS |
分子量 | 446.46 |
EINECS号 | |
相关类别 | Cyclic Nucleotide related |
Mol文件 | 73208-40-9.mol |
结构式 |
SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE 性质
储存条件 | −20°C |
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溶解度 | 可溶于水中 |
形态 | 固体 |
颜色 | 白色 |
Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)
A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission.
Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons.
安全信息
安全说明 | 22-24/25 |
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WGK Germany | 3 |
提供商 | 语言 |
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英文
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