[6-碘-2-甲基-1-[2-(4-吗啉基)乙基]-1H-吲哚-3-基](4-甲氧基苯基)甲酮
中文名称 | [6-碘-2-甲基-1-[2-(4-吗啉基)乙基]-1H-吲哚-3-基](4-甲氧基苯基)甲酮 |
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中文同义词 | [6-碘-2-甲基-1-[2-(4-吗啉基)乙基]-1H-吲哚-3-基](4-甲氧基苯基)甲酮;(6-碘-2-甲基-1-(2-吗啉-4-基乙基)-1H-吲哚-3-基)(4-甲氧基苯基)甲酮;6-碘-3-(4-甲氧基苯甲酰)-2-甲基-1-[2-(吗啉-4-基)乙基]-1H-吲哚;AM630,CB2 大麻素拮抗剂/反向激动剂 |
英文名称 | AM 630 |
英文同义词 | AM 630;6-IODO-2-METHYL-1-[[2-(4-MORPHOLINYL)ETHYL]-1H-INDOL-3-YL](4-METHOXYPHENYL)METHANONE;SC-200365(AM-630);1-[2-(Morpholin-4-yl)ethyl]-2-Methyl-3-(4-Methoxybenzoyl)-6-iodoindole;(6-iodo-2-Methyl-1-(2-Morpholinoethyl)-1H-indol-3-yl)(4-Methoxyphenyl)Methanone;AM630;AM 630;AM-630;Methanone, [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)-;Iodopravadoline (AM630) |
CAS号 | 164178-33-0 |
分子式 | C23H25IN2O3 |
分子量 | 504.36 |
EINECS号 | |
相关类别 | G蛋白偶联受体&G蛋白;抗体-二抗;Cannabinoid receptor |
Mol文件 | 164178-33-0.mol |
结构式 |
[6-碘-2-甲基-1-[2-(4-吗啉基)乙基]-1H-吲哚-3-基](4-甲氧基苯基)甲酮 性质
沸点 | 605.9±55.0 °C(Predicted) |
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密度 | 1.49±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | 二甲基亚砜:>5mg/mL |
酸度系数(pKa) | 6.98±0.10(Predicted) |
形态 | 粉末 |
颜色 | 白色至米色 |
Ki: 31.2 nM (CB 2 )
The AM251 and 6-Iodopravadoline (AM630)-evoked Ca 2+ influxes into TG sensory neurons aere concentration-dependent, and fitted. The EC 50 for AM251 and 6-Iodopravadoline are 7.37 μM and 15.6 μM, respectively. AM251 and 6-Iodopravadoline activate TRPA1 in TG sensory neurons. 6-Iodopravadoline is comparable in value in both TRPA1 and TRPV1/TRPA1 expressing CHO cells (2 and 4.6 μM, respectively). AM251 and 6-Iodopravadoline activation of TRPA1 is modulated by TRPV1. 6-Iodopravadoline (0, 50, 100, and 200 nM) is not toxic to RAW264.7 cells. 6-Iodopravadoline (100 nM) substantially inhibits osteoclastogenesis in cultures with RANKL and Ti particles in a dose-dependent manner. 6-Iodopravadoline (1 μM) blocks the CP-55,940 dose response with EC 50 of 170 nM at human and EC 50 of 110 nM at rat cannabinoid CB2 receptor.
6-Iodopravadoline (AM630) (2, 3 mg/kg, i.p.) significantly reduces the time spent in the light box compared with vehicle group. 6-Iodopravadoline (AM630) (1, 2 or 3 mg/kg, i.p., twice a day) produces a significant anxiolytic effect, increasing the time spent in the light box at all of the doses used.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2023/03/20 | HY-15421 | [6-碘-2-甲基-1-[2-(4-吗啉基)乙基]-1H-吲哚-3-基](4-甲氧基苯基)甲酮 6-Iodopravadoline | 164178-33-0 | 10mg | 1050元 |
2023/03/20 | HY-15421 | [6-碘-2-甲基-1-[2-(4-吗啉基)乙基]-1H-吲哚-3-基](4-甲氧基苯基)甲酮 6-Iodopravadoline | 164178-33-0 | 10mM * 1mLin DMSO | 1155元 |