ITE
| 中文名称 | ITE |
|---|---|
| 中文同义词 | 2-(1H-吲哚-3-基羰基)-4-噻唑羧酸甲酯;芳香烃受体(AHR)激动剂(ITE);化合物ITE;甲基 2-(1H-吲哚-3-羰基)-1,3-噻唑-4-甲酸基酯;ITE,内源性芳烃受体(AHR)激动剂 |
| 英文名称 | ITE |
| 英文同义词 | ITE;2-(1H-INDOL-3-YLCARBONYL)-4-THIAZOLECARBOXYLIC ACID METHYL ESTER;2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID;2-(1'H-indole-37-carbonyl)-thiasole-4-carboxylic acid methyl ester;Methyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate;methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate;ARYL HYDROCARBON RECEPTOR LIGAND;4-Thiazolecarboxylic acid, 2-(1H-indol-3-ylcarbonyl)-, methyl ester |
| CAS号 | 448906-42-1 |
| 分子式 | C14H10N2O3S |
| 分子量 | 286.31 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂;化工原料 |
| Mol文件 | 448906-42-1.mol |
| 结构式 |  |
ITE 性质
| 熔点 | 234 - 236°C |
|---|---|
| 沸点 | 520.4±48.0 °C(Predicted) |
| 密度 | 1.427±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO：30 mg/mL，可溶 |
| 酸度系数(pKa) | 14.38±0.30(Predicted) |
| 形态 | 固体 |
| 颜色 | 灰白色至浅黄色 |
Ki: 3 nM (AhR)
ITE is an endogenous agonist of AhR, binding directly to AHR, with a K i of 3 nM. ITE (0.03-30 mg/mL) decreases the antigen-specific T-cell proliferative responses. ITE potently inhibits human pulmonary artery endothelial (HPAECs) growth at 10 and 20 µM, but shows no effect at 0.01-5 µM. ITE does not affect cell cycle progress of HPAECs at 10 and 20 µM, or induce expression of cleaved caspase-3 protein in HPAECs at 20 µM. In addition, ITE (20 µM) elevates CYP1A1 and CYP1B1 mRNA levels and decreases the levels of AhR protein in HPAECs.
ITE (200 μg, i.p.) significantly suppresses the development of experimental autoimmune uveitis (EAU) in mice. ITE reduces the proportions of cells expressing IFN-γ, IL-17, or IL-10 in mice. ITE also suppresses the secretion of inflammatory cytokines by LN cells in mice.
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-19317 | ITE | 1 mg | 266元 | |
| 2024/01/25 | HY-19317 | ITE ITE | 448906-42-1 | 5mg | 650元 |