Tuftsin
| 中文名称 | Tuftsin |
|---|---|
| 中文同义词 | 吞噬刺激素;促吞噬素;增免疫苏精肽H-THR-LYS-PRO-ARG-OH;化合物TUFTSIN |
| 英文名称 | TUFTSIN |
| 英文同义词 | TUFTSIN;TUFTSIN 2ACOH 4H2O;THR-LYS-PRO-ARG;THR-LYS-PRO-ARG 2ACOH 4H2O;Tuftsin hydrate acetate salt;L-Thr-L-Lys-L-Pro-L-Arg-OH;Taftsin;Tuftsin Tuftsin acetate salt hydrate |
| CAS号 | 9063-57-4 |
| 分子式 | C21H40N8O6 |
| 分子量 | 500.59 |
| EINECS号 | |
| 相关类别 | 多肽;生化试剂;其他生化试剂;标准品;目录多肽;Peptide |
| Mol文件 | 9063-57-4.mol |
| 结构式 |  |
Tuftsin 性质
| 密度 | 1.48±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | −20°C |
| 酸度系数(pKa) | 3.60±0.21(Predicted) |
| 水溶解性 | Water : ≥ 160 mg/mL (319.62 mM) |
| 序列 | H-Thr-Lys-Pro-Arg-OH |
|
Human Endogenous Metabolite
|
Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages. Tuftsin's capacity to augment cellular activation is mediated by specific receptors that are identified, characterized, and recently isolated from rabbit peritoneal granulocytes. Tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune encephalomyelitis (EAE), a well-established animal model for MS. Tuftsin administration correlates with upregulation of the immunosuppressive Helper-2 Tcell (Th2) cytokine transcription factor GATA-3. Tuftsin promotes phagocytic activity for cells of monocytic origin, such as neutrophils, macrophages and microglia, all of which are thought to express Tuftsin receptors.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%