CS-2701
| 中文名称 | CS-2701 |
|---|---|
| 中文同义词 | 化合物E7820;血管生成抑制剂(E7820);3-氰基-N-(3-氰基-4-甲基-1H-吲哚-7-基)苯磺酰胺;E 7820,Α2整合素抑制剂 |
| 英文名称 | E-7820 |
| 英文同义词 | E-7820;ER 68203-00;3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide;N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide;E 7820; E-7820;CS-2701;ER68203-00;E7820;E-7820;E 7820;289483-69-8;Benzenesulfonamide, 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)- |
| CAS号 | 289483-69-8 |
| 分子式 | C17H12N4O2S |
| 分子量 | 336.37 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂;药物活性分子 |
| Mol文件 | 289483-69-8.mol |
| 结构式 |  |
CS-2701 性质
| 沸点 | 626.2±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.48±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO:67.0(最大浓度 mg/mL);199.19(最大浓度 mM) |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 8.17±0.30(Predicted) |
E7820 (ER68203-00) inhibits both bFGF- and VEGF-driven ube formation of human umbilical vascular endothelial cell (HUVEC) in a dose-dependent manner with IC
50
of 0.20 and 0.24 μg/ml, respectively.
E7820 inhibits proliferation of HUVEC induced by either bFGF or VEGF in serum-free medium (SFM). The IC
50
values are 0.10 and 0.081 μg/ml, respectively. Antiproliferative activity of E7820 against both WiDr and LoVo cells is very weak compared with that against HUVEC. The values of IC50 were 29 and 15 μg/ml, respectively.
E7820 (ER68203-00) (50-200 mg/kg; p.o. ; twice daily for 14 days) delays the growth of WiDr cells inoculated s.c..
E7820 (200-400 mg/kg; p.o.;once daily for 4 days) potently inhibits WiDr-induced angiogenesis.
| Animal Model: | Six-week-old female nude mice (KSN mice, WiDr-induced angiogenesis model) |
| Dosage: | 50, 100, 200 mg/kg |
| Administration: | p.o. ; twice daily for 14 days from 2 days after inoculation of the tumor cells |
| Result: | The antitumor effect was dose-dependent at 50, 100, and 200 mg/kg, and the tumor growth rates were 52%, 46%, and 27%, respectively. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-14571 | E7820 | 1 mg | 431元 | |
| 2024/01/25 | HY-14571 | CS-2701 E7820 | 289483-69-8 | 5mg | 950元 |