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CYCLOTHIAZIDE

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Company Name: career henan chemical co
Tel: 0086-371-86658258
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Products Intro: Product Name:CYCLOTHIAZIDE
CAS:2259-96-3
Purity:99% Package:1g;1USD
Company Name: Shaanxi Dideu Medichem Co. Ltd
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Products Intro: Product Name:Cyclothiazide
CAS:2259-96-3
Purity:99% Package:1g;1USD|10g;1USD|100g;1USD|1KG;1USD|25KG;1USD
Company Name: Target Molecule Corp
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Products Intro: Product Name:Cyclothiazide
CAS:2259-96-3
Purity:100.00% Package:5 mg;10 mg;25 mg;50 mg;100 mg;1 mL * 10 mM (in DMSO);2 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Dideu Industries Group Limited
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Products Intro: Product Name:CYCLOTHIAZIDE USP/EP/BP
CAS:2259-96-3
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: J & K SCIENTIFIC LTD.  
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Products Intro: Product Name:Cyclothiazide
CAS:2259-96-3
Purity:>98% Package:100Mg,1g

Lastest Price from CYCLOTHIAZIDE manufacturers

  • Cyclothiazide
  • US $1.00-1.00 / KG
  • 2020-05-12
  • CAS:2259-96-3
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
  • CYCLOTHIAZIDE
  • US $1.00 / g
  • 2019-12-31
  • CAS:2259-96-3
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 200kg
CYCLOTHIAZIDE Basic information
Product Name:CYCLOTHIAZIDE
Synonyms:2,4-benzothiadiazine-3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-4-dihydro-2h-1;2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-chloro-3-(5-norbornen-2-yl)-,1,1-dioxide;2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide;2h-1,2,4-benzothiadiazine-7-sulfonamide,3-bicyclo(2.2.1)hept-5-en-2-yl-6-chlor;35483;4-benzothiadiazine-7-sulfonamide,3,4-dihydro-6-chloro-3-(5-norbornen-2-2h-2;mdi193;o-3,4-dihydro-,1,1-dioxide
CAS:2259-96-3
MF:C14H16ClN3O4S2
MW:389.88
EINECS:218-859-7
Product Categories:Glutamate;Glutamate receptor;Amines;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:2259-96-3.mol
CYCLOTHIAZIDE Structure
CYCLOTHIAZIDE Chemical Properties
Melting point 234°
density 1.3781 (rough estimate)
refractive index 1.6100 (estimate)
storage temp. 2-8°C
form White to off-white solid.
pkapKa 9.1(30% EtOH) (Uncertain)
λmax273nm(lit.)
Merck 14,2754
EPA Substance Registry System2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide (2259-96-3)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 2
RTECS DK9610000
HS Code 2935904000
ToxicityLD50 oral in rat: > 5gm/kg
MSDS Information
ProviderLanguage
SigmaAldrich English
CYCLOTHIAZIDE Usage And Synthesis
OriginatorAnhydron,Lilly,US,1963
UsesDiuretic; antihypertensive. A subunit-specific inhibitor of GABAC receptors
DefinitionChEBI: 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted at positions 3, 5 and 6 by a 2-norbornen-5-yl group, chlorine, and a sulfonamide group, respectively. A thiazide diuretic, it has been used in the management of hypertension a d oedema.
Manufacturing ProcessA mixture of 8.5 g (0.03 mol) of 6-chloro-4-amino-benzene-1,3- disulfonamide, 4.0 g (0.033 mol) of 2,5-endomethylene-δ3- tetrahydrobenzaldehyde and 25 cc of diethyleneglycol-dimethyl ether was heated for 2 hours at 100°C. During this time the major portion of the initially undissolved crystals went into solution; thereafter, the reaction mixture was allowed to stand for 14 hours at room temperature, during which the remaining undissolved crystals also went into solution. The reddish, clear solution thus obtained was admixed with 50 cc of chloroform. The greyishwhite precipitate formed thereby was separated by vacuum filtration, washed with a small amount of chloroform, dried and recrystallized from aqueous methanol. 7.5 g of white crystalline needles having a melting point of 229° to 230°C were obtained.
Brand nameAnhydron (Lilly).
Therapeutic FunctionDiuretic, Antihypertensive
Biological ActivityPositive allosteric modulator of AMPA receptors that potently inhibits AMPA receptor desensitization. Selective for the flip variant of each of the four receptor subunits. Also available as part of the AMPA Receptor Tocriset™ .
CYCLOTHIAZIDE Preparation Products And Raw materials
Raw materials4-Amino-6-chlorobenzene-1,3-disulfonamide
Tag:CYCLOTHIAZIDE(2259-96-3) Related Product Information
(RS)-AMPA Comphene Chlorothiazide Camphene Aminomethylcyclopentane hydrochloride Hydrochlorothiazide butizide mebutizide Benzenesulfonamide, 2-(methylamino)- (9CI) CYCLOTHIAZIDE CLOFENAMIDE 2-amino-N-propylbenzenesulfonamide 4-Amino-6-chlorobenzene-1,3-disulfonamide ethiazide 2-AMINO-N-METHYLBENZENESULFONAMIDE 4-CHLORO-1,3-BENZENEDITHIOL N-(5-NORBORNENE-2-METHYL)-METHANESULFONAMIDE 2-AMINO-N-BUTYLBENZENESULFONAMIDE