| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532 |
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jkinfo@jkchemical.com |
| Products Intro: |
Product Name:R-(-)-Flecainide
CAS:99495-90-6
Package:10Mg,1Mg
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:R-(-)-Flecainide;N-[(2R)-2-PiperidinylMethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzaMide;
(R)-Flecainide; (-)-Flecainide
CAS:99495-90-6
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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| Company Name: |
S.Z. PhyStandard Bio-Tech. Co., Ltd.
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| Tel: |
0755-83725681-603 |
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| Products Intro: |
Product Name:R-(-)-Flecainide
CAS:99495-90-6
Purity:98% HPLC Package:10mg/25mg/50mg/100mg
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:R-(-)-Flecainide
CAS:99495-90-6
Purity:>95%
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| | (R)-Flecainide Basic information |
| Product Name: | (R)-Flecainide | | Synonyms: | (R)-(-)-Flecainide;(R)-Flecainide;Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, (R)-;Benzamide, N-[(2R)-2-piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)-;N-[(2R)-2-Piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide;N-[(R)-2-Piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide;N-[[(2R)-piperidin-2-yl]methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide | | CAS: | 99495-90-6 | | MF: | C17H20F6N2O3 | | MW: | 414.34 | | EINECS: | | | Product Categories: | Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 99495-90-6.mol |  |
| | (R)-Flecainide Chemical Properties |
| Boiling point | 434.9±45.0 °C(Predicted) | | density | 1.286±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Ethanol: soluble; Methanol: soluble | | form | A solid | | pka | 14.15±0.46(Predicted) | | color | White to off-white |
| | (R)-Flecainide Usage And Synthesis |
| Description | R-(–)-Flecainide is the (R) enantiomer of the antiarrhythmic agent flecainide . R-(–)-Flecainide prevents chloroform-induced ventricular fibrillation in mice (ED50 = 14.5 mg/kg). It also prevents ouabain-induced ectopic ventricular tachycardia in anesthetized dogs. | | Uses | R-Enantiomer of Flecainide. Antiarrhythmic (class IC). | | in vivo | R-(–)-Flecainide inhibits chloroform-induced fibrillation (9-20 mg/kg, po, single dose) in mice model with an ED50 of 14.5 mg/kg, and inhibits ouabain induced arrhythmias (1-3 mg/kg, ) in mongrel dog model, without toxicity[1]. | Animal Model: | Chloroform-induced ventricular fibrillation in mice[1] | | Dosage: | 9-20 mg/kg | | Administration: | po, single dose | | Result: | Prevented fibrillation. |
| Animal Model: | Ouabain induced ventricular tachycardia in mongrel dog[1] | | Dosage: | 1-3 mg/kg | | Administration: | iv, single dose | | Result: | Inhibited arrhythmias. |
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| | (R)-Flecainide Preparation Products And Raw materials |
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