| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
| Products Intro: |
Product Name:Territrem A
CAS:70407-19-1
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Territrem A
CAS:70407-19-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | territrem A Basic information |
| Product Name: | territrem A | | Synonyms: | territrem A;(4aR)-4a,6,6a,12,12a,12b-Hexahydro-4aβ,12aβ-dihydroxy-9-(7-methoxy-1,3-benzodioxol-5-yl)-4,4,6aα,12bα-tetramethyl-4H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-1,11(5H)-dione;TERRITREM A(RG);PubChem ID: 115079;4H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexahydro-4a,12a-dihydroxy-9-(7-methoxy-1,3-benzodioxol-5-yl)-4,4,6a,12b-tetramethyl-, (4aR,6aR,12aS,12bS)- | | CAS: | 70407-19-1 | | MF: | C28H30O9 | | MW: | 510.53 | | EINECS: | | | Product Categories: | | | Mol File: | 70407-19-1.mol |  |
| | territrem A Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble | | form | A solid |
| | territrem A Usage And Synthesis |
| Description | Territrem A is a mycotoxin originally isolated from A. terreus that irreversibly inhibits acetylcholinesterase (AChE; IC50 = 24 nM for the electric eel enzyme). It is toxic to mice, inducing tremors with a median tremulous dose of 0.31 mg/kg, and has an LD50 value of 17.6 mg/kg. | | Uses | Territrem A is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem A is a potent insecticide acting via irreversible inhibition of acetylcholinesterase (AChE). The binding mechanism is very different from typical irreversible AChE inhibitors like neostigmine and the organophospates. | | References | Territrems, tremorgenic mycotoxins of Aspergillus terreus. Ling K.L. et al., Appl. Env. Microbiol. 1979, 37, 355.
Toxicity and anticholinesterase activity of the fungal metabolites territrems to the corn earworm, Helicoverpa zea. Dowd P.F. et al., Entomol. Exp. Appl. 1992, 65, 57.
Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism. Jen-Wei Chen J-W. et al., J. Biol. Chem. 1999, 274, 34916. |
| | territrem A Preparation Products And Raw materials |
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