TP 508
| 中文名称 | TP 508 |
|---|---|
| 中文同义词 | H-ALA-GLY-TYR-LYS-PRO-ASP-GLU-GLY-LYS-ARG-GLY-ASP-ALA-CYS-GLU-GLY-ASP-SER-GLY-GLY-PRO-PHE-VAL-OH;非蛋白水解凝血酶肽TP508 |
| 英文名称 | TP 508 |
| 英文同义词 | TP 508;L-Valine, L-alanylglycyl-L-tyrosyl-L-lysyl-L-prolyl-L-α-aspartyl-L-α-glutamylglycyl-L-lysyl-L-arginylglycyl-L-α-aspartyl-L-alanyl-L-cysteinyl-L-α-glutamylglycyl-L-α-aspartyl-L-serylglycylglycyl-L-prolyl-L-phenylalanyl- |
| CAS号 | 121341-81-9 |
| 分子式 | C97H146N28O36S |
| 分子量 | 2312.46 |
| EINECS号 | 206-141-6 |
| 相关类别 | |
| Mol文件 | 121341-81-9.mol |
| 结构式 |  |
TP 508 性质
| 密度 | 1.56±0.1 g/cm3(Predicted) |
|---|---|
| InChIKey | MOZAQZCGIKWACU-BRMVNBHNNA-N |
TP508 (50 μg/mL; 24 hours; HCAEC) treatment reverses radiation-induced endothelial dysfunction (ED) and loss of NO signaling by attenuating the downregulation of eNOS expression. TP508 treatment is able to stimulate NO production in the irradiated cells.
TP508 mitigates effects of nuclear radiation on human endothelial cells in culture restoring endothelial NO production, tube formation and accelerating repair of radiation-induced DNA double-strand breaks (DSB).
TP508 acts as an antagonist for the effects of thrombin. TP508 peptide inhibits these thrombin-induced effects through a RGD and αvβ3-related mechanism.
Western Blot Analysis
| Cell Line: | Primary human coronary artery endothelial cells (HCAEC) |
| Concentration: | 50 μg/mL |
| Incubation Time: | 24 hours |
| Result: | Prevented the radiation-induced downregulation of eNOS. |
TP508 (10 mg/kg; intravenous injection; male CD-1 mice) treatment mitigates radiation-induced endothelial cell damage, also significantly increases survival of CD-1 mice when injected 24 h after 8.5 Gy exposure.
| Animal Model: | Male CD-1 mice (12-15-week old) with γ irradiation |
| Dosage: | 10 mg/kg |
| Administration: | Intravenous injection |
| Result: | Mitigated radiation-induced endothelial cell damage, also significantly increased survival of CD-1 mice. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2023/03/20 | HY-P0316 | TP 508 TP508 | 121341-81-9 | 1mg | 1200元 |
| 2023/03/20 | HY-P0316 | TP 508 TP508 | 121341-81-9 | 5mg | 4800元 |