头孢吡普
| 中文名称 | 头孢吡普 |
|---|---|
| 中文同义词 | 头孢吡普;头孢托罗;(6R,7R)-7-((Z)-2-(5-氨基-1,2,4-噻二唑-3-基)-2-(羟基亚氨基)乙酰胺基)-8-氧代-3-((E)-((R)-2-氧代-[1,3'-联吡咯烷]-3-亚基)甲基)-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸 |
| 英文名称 | Ceftobiprole |
| 英文同义词 | Ceftobiprole;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(5-aMino-1,2,4-thiadiazol-3-yl)-2-(hydroxyiMino)acetyl]aMino]-8-oxo-3-[(E)-[(3'R)-2-oxo[1,3'-bipyrrolidin]-3-ylidene]Methyl]-,(6R,7R)-;CS-734;BAL 9141;cephalosporin,Ceftobiprole,inhibit,vancomycin,penicillin,staphylococci,Bacterial,pyrrolidinone,pathogens,gram-positive,BAL-9141,VRSA,gram-negative,Inhibitor,MRSA,BAL9141,methicillin;Abscisic Acid Impurity 4 |
| CAS号 | 209467-52-7 |
| 分子式 | C20H22N8O6S2 |
| 分子量 | 534.57 |
| EINECS号 | |
| 相关类别 | 贝尔卡主打 |
| Mol文件 | 209467-52-7.mol |
| 结构式 |  |
头孢吡普 性质
| 密度 | 2.00±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C,unstable in solution, ready to use. |
| 溶解度 | 二甲基亚砜：5 mg/mL（9.35 mM） |
| 酸度系数(pKa) | 2.46±0.50(Predicted) |
MIC90: 2 μg/mL (MRSA)
Ceftobiprole has demonstrates activity against important gram-positive bacteria, including S. pneumonia (PRSP), Methicillin-resistant S. aureus (MRSA), and E. faecalis with MIC 90 values of 0.25, 2, and 2 mcg/mL, respectively. Ceftobiprole has also demonstrated potent in vitro activity against several clinical isolates of community-associated Methicillin-resistant S. aureus (CA-MRSA), S. aureus (VISA), and S. aureus (VRSA), with a minimum inhibitory concentration (MIC) of 2 mcg/mL. Ceftobiprole is highly active against S. aureus, withMICs ranging from 0.12 to 4 mg/L (only one resistant strain,MIC of 4 mg/L). Furthermore, Ceftobiprole is twice more active on Methicillin-susceptible S. aureus (MSSA) strains with MIC 50 and MIC 90 of 0.5 mg/L than on MRSA strains with MIC 50 and MIC 90 of 1 mg/L. Moreover, Panton-Valentine leukocidin (PVL)+MRSA are slightly more susceptible to Ceftobiprole (MIC 50 of 0.5 mg/L and MIC 90 of 1 mg/L) than PVL-MRSA (MIC 50 and MIC 90 of 1 mg/L).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-112579 | 头孢吡普 Ceftobiprole | 209467-52-7 | 5mg | 3100元 |
| 2024/04/30 | HY-112579 | 头孢吡普 Ceftobiprole | 209467-52-7 | 10mg | 4500元 |