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| | FR 122047 HYDROCHLORIDE Basic information |
| Product Name: | FR 122047 HYDROCHLORIDE | | Synonyms: | 4,5-BIS(4-METHOXYPHENYL-2-[(1-METHYLPIPERAZIN-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE;4,5-BIS(4-METHOXYPHENYL)-2-[(1-METHYLPIPERAZINE-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE;1-[[4,5-BIS(4-METHOXYPHENYL)-2-THIAZOLYL]CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE;1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE;FR 122047;FR 122047 HYDROCHLORIDE;FR122047HCl;(4,5-Bis(4-Methoxyphenyl)thiazol-2-yl)(4-Methylpiperazin-1-yl)Methanone hydrochloride | | CAS: | 130717-51-0 | | MF: | C23H26ClN3O3S | | MW: | 459.99 | | EINECS: | | | Product Categories: | Prostanoid receptor and related | | Mol File: | 130717-51-0.mol |  |
| | FR 122047 HYDROCHLORIDE Chemical Properties |
| storage temp. | 2-8°C | | solubility | methylene chloride: 50 mg/mL, slightly hazy, yellow | | form | powder | | color | faint yellow | | Water Solubility | Soluble to 10 mM in water |
| | FR 122047 HYDROCHLORIDE Usage And Synthesis |
| Description | FR122047 is a selective inhibitor of COX-1. The IC50 values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC50 of 180-200 nM, which is nearly 100 times more potent than aspirin. Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models. | | Uses | FR 122047 Hydrochloride is a selective cyclooxygenase-1 (Cox-1) inhibitor. | | Biological Activity | Selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.028 and 65 μ M for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo . | | storage | Desiccate at +4°C |
| | FR 122047 HYDROCHLORIDE Preparation Products And Raw materials |
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