125941-87-9
| 中文名称 | 125941-87-9 |
|---|---|
| 中文同义词 | 化合物SCH 23390 HYDROCHLORIDE;(R)-8-氯-3-甲基-5-苯基-2,3,4,5-四氢-1H-苯并[D]氮杂卓-7-醇盐酸盐;SCH 23390 盐酸盐 |
| 英文名称 | R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride |
| 英文同义词 | R(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE;SCH 23390 HYDROCHLORIDE;R(+)-SCH-23390 HYDROCHLORIDE SELECTIVE D 1 DOPAMINE;(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride;SCH 23390(HCI);(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC);R(+)-SCH-23390;R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine |
| CAS号 | 125941-87-9 |
| 分子式 | C17H18ClNOHCl |
| 分子量 | 324.24 |
| EINECS号 | |
| 相关类别 | Dopamine receptor;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 125941-87-9.mol |
| 结构式 |  |
125941-87-9 性质
| 比旋光度 | +27～+31°(D/20℃)(c=0.5,DMF) |
|---|---|
| 储存条件 | protect from light |
| 溶解度 | 在水中的溶解度>5mg/mL |
| 形态 | 固体 |
| 颜色 | 白色 |
| 旋光性 (optical activity) | [α]/D +32.1°, c = 1 in DMF(lit.) |
| EPA化学物质信息 | (5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride (125941-87-9) |
| Target | Value |
|
D1 dopamine receptor
(Cell-free assay) | 0.2 nM(Ki) |
|
D5 dopamine receptor
(Cell-free assay) | 0.3 nM(Ki) |
|
h5-HT2C receptor
(Cell-free assay) | 9.3 nM(Ki) |
|
GIRK
(Cell-free assay) | 268 nM |
SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway.
SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D
1
receptors in rodents, nonhuman primates, and humans.
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat.
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O
2
conditions.
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-19545A | SCH-23390 hydrochloride | 1 mg | 350元 | |
| 2024/01/25 | HY-19545A | 125941-87-9 SCH-23390 hydrochloride | 125941-87-9 | 5mg | 770元 |