盐酸青藤碱
中文名称 | 盐酸青藤碱 |
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中文同义词 | 盐酸青藤碱(标准品);SINOMENINE HYDROCHLORIDE 盐酸青藤碱;SINOMENINE HYDROCHLORIDE 盐酸青藤碱 标准品;盐酸青藤碱(分析标准品);盐酸防己碱;藤根提取物;藤根提取物-青藤碱;(4BR,8AS,9S)-4-羟基-3,7-二甲氧基-11-甲基-9,10-二氢-5H-9,4B-(EPIMINOETHANO)菲-6-6(8AH)-酮 盐酸盐 |
英文名称 | SINOMENINE HYDROCHLORIDE |
英文同义词 | (9a,13a,14a)-4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one hydrochloride;SINOMENINE HYDROCHLORIDE;SINOMENINE HCL;(9α,13α,14α)- 7,8-Didehydro-4- hydroxy-3,7-diMet;7,8-Didehydro-4-hydroxy-3,7-diMethoxy-17-Methyl- 9α,13α,14α-Morphinan-6-one Hydrochloride;Tuduranine Hydrochloride;hydroxy-dimethoxy-methyl-BLAH-azatetracyclo[BLAH]hexadeca-BLAH,BLAH,BLAH,BLAH-tetraenone;Sinomenine Hydrocloride |
CAS号 | 6080-33-7 |
分子式 | C19H24ClNO4 |
分子量 | 365.85 |
EINECS号 | |
相关类别 | 植物生化提取物;中药标准品;标准品;植物提取物;对照品;中药对照品;原料;小分子抑制剂;小分子抑制剂,天然产物;植物成分单体;分析试剂标准品;标准品-对照品;标准品-中药标准品;标准品,对照品;生物碱;APIs;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Alkaloids;标准品 -中药标准品;植物提取物单体;医药、农药及染料中间体;化工原料;有机化工原料;科研原料 |
Mol文件 | 6080-33-7.mol |
结构式 |
盐酸青藤碱 性质
熔点 | 231.0 to 235.0 °C |
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储存条件 | Inert atmosphere,2-8°C |
溶解度 | 在水中的溶解度为20mg/mL,澄清 |
形态 | 粉末 |
颜色 | 白色至米色 |
旋光性 (optical activity) | [α]/D -70 to -90°, c = 1 in H2O |
水溶解性 | Soluble to 100 mM in water |
NF-κB
|
μ-opioid receptor
|
Cell viability is gradually decreased with increasing Sinomenine hydrochloride concentration. The migration ability of MDA-MB-231 cells is significantly weakened by 0.25, 0.5, and 1 mM of Sinomenine hydrochloride treatment. The wound-healing assay reveals that 0.25 and 0.5 mM Sinomenine hydrochloride significantly suppress the healing of the wound. When the MDA-MB-231 cells are treated with 0.5 mM Sinomenine hydrochloride, the healing progress is about 50%, but in the group treated with 0.25 mM Sinomenine hydrochloride and the untreated control, the healing is about 80% and nearly 95%, respectively. The IB assay following inhibitor of NF-κB (IκB) antibody IP shows that the binding of NF-κB to IκB is inhibited by Sinomenine hydrochloride treatment in a dose-dependent manne.
Sinomenine hydrochloride (i.p.) produces antinociception in the hot plate and tail flick tests in male rats at 40 mg/kg, but not at lower doses (10 or 20 mg/kg). At 10 to 40 mg/kg Sinomenine hydrochloride does not produce any observable side effect such as sedation, allergy or motor impairments. At 80 mg/kg, Sinomenine hydrochloride is mildly sedative in rats. Sinomenine hydrochloride at 80 mg/kg i.p. does not produce any observable side effects in mice. I.p or p.o. Sinomenine hydrochloride at 40 or 80 mg/kg dose-dependently reduces mechanical hypersensitivity in nerve injured mice. I.p. Sinomenine hydrochloride at 40 mg/kg, but not lower doses or vehicle, significantly decreases mechanical and cold allodynia for up to 240 min without producing motor deficits or sedation. At doses of 10 to 40 mg/kg, Sinomenine hydrochloride dose-dependently increases the paw withdrawal threshold. In non-chronic constriction injury (CCI) healthy rats, Sinomenine hydrochloride at the dose range of 10 to 40 mg/kg does not change the immobility behavior in the forced swimming test.
药理药效:具有祛风除湿,活血通络,利尿消肿的作用。
安全信息
安全说明 | 24/25 |
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WGK Germany | 3 |
RTECS号 | QD2163000 |
海关编码 | 29334900 |