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| | MECLOCYCLINE SULFOSALICYLATE SALT Basic information |
| Product Name: | MECLOCYCLINE SULFOSALICYLATE SALT | | Synonyms: | MECLOCYCLINE SULFOSALICYLATE SALT;MECLOCYLINESULFOSALICYLATE;2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4A,5,5A,6,11,12A-octahydro-3,5,10,12,12A-pentahydroxy-6-methylene-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,12aalpha))-, mono(2-hydroxy-5-sulfobenzoate) (salt);Benzoic acid, 2-hydroxy-5-sulfo-, compd. with (4S-(4alpha,4aalpha,5alpha,5aalpha,12aalpha))-7-chloro-4-(dimethylamino)-1,4,4A,5,5A,6,11,12A-octahydro-3,5,10,12,12A-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide (1:1);Einecs 277-614-2;Meclan;Meclocycline 5-sulfosalicylate;Mecloderm | | CAS: | 73816-42-9 | | MF: | C29H27ClN2O14S | | MW: | 695.05 | | EINECS: | 277-614-2 | | Product Categories: | 1694 Pharmaceuticals&Personal Care Products;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics G-MAntibiotics;Chemical Structure Class;Interferes with Protein SynthesisSpectrum of Activity;L - ZEPA;Mechanism of Action;NeatsAntibiotics;Tetracyclines | | Mol File: | 73816-42-9.mol |  |
| | MECLOCYCLINE SULFOSALICYLATE SALT Chemical Properties |
| Melting point | >193°C (dec.) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | methanol: soluble10ML, clear, very dark yellow (200 mg + 10 mL MeOH) | | form | Solid | | color | yellow-green powder | | Stability: | Hygroscopic |
| WGK Germany | 3 | | HS Code | 2941300000 |
| | MECLOCYCLINE SULFOSALICYLATE SALT Usage And Synthesis |
| Uses | Antibacterial;Antibacterial | | Uses | Meclocycline Sulfosalicylate Salt is a salt prepared from demeclocycline taking advantage of the basic dimethylamino group which protonates and readily forms a salt in solution with 2-hydroxy-3-carboxybenenesulphonic acid. Like all tetracyclines, meclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis. The unusual complex counter-ion is likely to add an antiseptic component to the use of the compound for skin infections. | | Uses | Meclocycline is a tetracycline antibiotic that is topically used for skin infections and irritations. | | Brand name | Meclan (Johnson & Johnson). | | General Description | Meclocycline, 7-chloro-6-deoxy-6-demethyl-6-methylene-5-oxytetracycline sulfosalicylate (Meclan), is a semisyntheticderivative prepared from oxytetracycline.Although meclocycline has been used in Europe for manyyears, it became available only relatively recently in theUnited States for a single therapeutic indication, the treatmentof acne. It is available as the sulfosalicylate salt in a1% cream.
Meclocycline sulfosalicylate is a bright yellow, crystallinepowder that is slightly soluble in water and insolublein organic solvents. It is light sensitive and should be storedin light-resistant containers. |
| | MECLOCYCLINE SULFOSALICYLATE SALT Preparation Products And Raw materials |
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