|
|
| | CX-4945 Basic information |
| Product Name: | CX-4945 | | Synonyms: | 5-[(3-chlorophenyl)amino]-Benzo[c]-2,6-naphthyridine-8-carboxylic acid;CX-4945;Silmitasertib;CX-4945 Silmitasertib;CX-4945, CX4945;Silmitasertib(CX-4945);5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylic acid CX-4945 (Silmitasertib);CX-4945, >=98% | | CAS: | 1009820-21-6 | | MF: | C19H12ClN3O2 | | MW: | 349.77 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1009820-21-6.mol |  |
| | CX-4945 Chemical Properties |
| Boiling point | 568.5±50.0 °C(Predicted) | | density | 1.490 | | storage temp. | Store at -20°C | | solubility | ≥103.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH | | form | Orange powder. | | pka | 2.96±0.30(Predicted) |
| | CX-4945 Usage And Synthesis |
| Uses | CX-4945 is a protein kinase CK2 inhibitor resulting in cancer cell death and prevention of proliferation. Anti-leukemia agent. | | Biological Activity | cx-4945 (silmitasertib) is a potent and selective casein kinase 2 (ck2) inhibitor with ic50 value of 1 nm. it is atp-competitive and can be taken orally [1].cx-4945 has been reported to have antiproliferative activity against a wide range of tumor cell lines. it is suggested that cx-4945 suppresses the ck2 regulated pi3k/akt signaling pathway by inhibiting akt phosphorylation at serine 129, but not by activating pten. additionally, cells treated with cx-4945 had a reduction of p21 phophorylation and an up-regulations of total p21 and p27. cx-4945 has been shown to induce cell-cycle arrest at g2/m phase in breast cancer cell line bt-474. it also causes cell-cycle arrest at g1 phase the breast cancer cell line bxpc-3) [1].in cx-4945 and bxpc-3 derived mouse xenograft model, cx-4945 induced a reduction of phos-p21 expression along with anti-carcinoma effects [1] | | references | [1] siddiqui-jain a1, drygin d, streiner n, chua p, pierre f, o'brien se, bliesath j, omori m, huser n, ho c, proffitt c, schwaebe mk, ryckman dm, rice wg,anderes k. cx-4945, an orally bioavailable selective inhibitor of protein kinase ck2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. cancer res. 2010 dec 15; 70 (24): 10288-98. |
| | CX-4945 Preparation Products And Raw materials |
|