887603-94-3
中文名称 | 887603-94-3 |
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中文同义词 | 1',3'-二氢-2H-螺[咪唑并[1,2-A]吡啶-3,2'-茚]-2-酮;化合物ZSET-1446;1',3'-二氢-2H-螺[咪唑并[1,2-A]吡啶-3,2'-茚]-2-酮 |
英文名称 | ST101 |
英文同义词 | ST101;ZSET 1446;ST 101(ZSET1446);1,3-DIHYDRO-2H-SPIRO[IMIDAZO[1,2-A]PYRIDINE-3,2-INDEN]-2-ONE;ST101;ZSET-1446;ZSET 1446;ST-101;ST 101;Spiro[imidazo[1,2-a]pyridine-3(2H),2'-[2H]inden]-2-one, 1',3'-dihydro-;ST101,Inhibitor,ST 101,Calcium Channel,Nicotinic acetylcholine receptors,Ca2+ channels,ZSET 1446,ZSET1446,inhibit,nAChR,Ca channels;1',3'-Dihydro-2H-spiro[imidazo[1,2-a]pyridine-3,2'-inden]-2-one |
CAS号 | 887603-94-3 |
分子式 | C15H12N2O |
分子量 | 236.27 |
EINECS号 | |
相关类别 | 贝尔卡主打 |
Mol文件 | 887603-94-3.mol |
结构式 |
887603-94-3 性质
沸点 | 403.4±55.0 °C(Predicted) |
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密度 | 1.32±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:≥34mg/mL(143.90mM) |
形态 | 固体 |
酸度系数(pKa) | 3.13±0.20(Predicted) |
颜色 | 浅黄至卡其色 |
ZSET1446 (100 pM-10 nM) exerts limited effects on the basal neuronal excitability and synaptic transmission. ZSET1446 potentiates the facilitatory effect of nAChR stimulation on sPSC frequency. ZSET1446 potentiates the increase in sIPSC frequency by local application of nicotine (5 µM; 2 minutes) without affecting the basal sIPSC frequency at the range of 10 pM to 1 nM.
ZSET1446 enhances object recognition memory in mice and ameliorates cognitive impairment caused by scopolamine in rats. Concomitant administration of subeffective doses of ZSET1446 and memantine significantly ameliorates the cognitive performance in the novel object recognition task in both mice and rats. Moreover, oral administration of ZSET1446 or memantine increases the extracellular level of ACh in the hippocampus as compared with the control. Further, concomitant administration of subeffective doses of ZSET1446 and memantine significantly increases the extracellular level of ACh as compared with the group of ZSET1446 or memantine alone. ZSET1446 (0.002, 0.01, and 0.1 mg/kg, p.o.) ameliorates cognitive deficits of SAMP8 after 4, 8, 12, and 16 weeks of treatment in a novel object recognition test. ZSET1446 also reduces grading scores of SAMP8 after 16 weeks of treatment. Further, 8-week treatment of ZSET1446 significantly reduces the total number of Aβ-positive granules in the hippocampus.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-11013 | ZSET1446 | 1 mg | 900元 | |
2024/08/19 | HY-11013 | 887603-94-3 ZSET1446 | 887603-94-3 | 5mg | 2250元 |