3,3'-[2,6-吡啶二基二(羰基亚氨基)]二[1-甲基喹啉鎓]
中文名称 | 3,3'-[2,6-吡啶二基二(羰基亚氨基)]二[1-甲基喹啉鎓] |
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中文同义词 | 3,3'-[2,6-吡啶二基二(羰基亚氨基)]二[1-甲基喹啉鎓];3,3'-[2,6-吡啶二基二(羰基亚氨基)]二[1-甲基喹啉];化合物360A;360A,一种 G-四联体 (G-QUADRUPLEX) 的稳定剂 |
英文名称 | 360 A |
英文同义词 | 360 A;360A;3,3'-[2,6-Pyridinediylbis(carbonylimino)]bis[1-methylquinolinium];360A;360 A;360A,Telomerase,inhibit,Inhibitor,G-quadruplex |
CAS号 | 794458-56-3 |
分子式 | C27H23N5O2+2 |
分子量 | 449.50382 |
EINECS号 | |
相关类别 | 细胞周期 |
Mol文件 | 794458-56-3.mol |
结构式 |
3,3'-[2,6-吡啶二基二(羰基亚氨基)]二[1-甲基喹啉鎓] 性质
储存条件 | Store at -20°C |
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溶解度 | 25℃:二甲基亚砜 |
形态 | 粉末 |
IC50: 300 nM (Telomerase)
G-quadruplex
360A inhibits telomerase activity and stabilizes G-quadruplex, with an IC 50 of 300 nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC 50 s of 4.8 ± 1.1 μM, 3.9 ± 0.4 μM, 8.4 ± 0.5 μM, >15 μM and 17.4 ± 1.2 μM, respectively. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions.