地拉罗斯铁螯合物
中文名称 | 地拉罗斯铁螯合物 |
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中文同义词 | 地拉罗斯铁螯合物;化合物 T13639;地拉罗司铁螯合物;地拉罗司铁螯合物(地拉罗司杂质23) |
英文名称 | Exjade Fe3+ chelate |
英文同义词 | Deferasirox (Fe3+ chelate);Exjade Fe3+ chelate;[4-[3,5-Bis[2-hydroxy)phenyl]-1H-1,2,4-triazol-1-yl]benzoato)]iron;Deferasirox Fe3(addition) chelate |
CAS号 | 554435-83-5 |
分子式 | C21H12FeN3O4 |
分子量 | 426.19 |
EINECS号 | |
相关类别 | |
Mol文件 | 554435-83-5.mol |
结构式 |
地拉罗斯铁螯合物 性质
储存条件 | Store at -20°C |
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溶解度 | 溶于二甲基亚砜 |
形态 | 粉末 |
Deferasirox is the first oral medication approved in the USA for this purpose. The half-life of deferasirox is between 8 and 16 hours allowing once a day dosing. Two molecules of deferasirox are capable of binding to 1 atom of iron which are subsequently eliminated by fecal excretion. Its low molecular weight and high lipophilicity allows the drug to be taken orally unlike desferoxamine which has to be administered by IV route (intravenous infusion). Together with deferiprone, deferasirox seems to be capable of removing iron from cells (cardiac myocytes and hepatocytes) as well as removing iron from the blood.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-16564 | 地拉罗斯铁螯合物 Deferasirox (Fe3+ chelate) | 554435-83-5 | 2mg | 1002元 |
2024/01/25 | HY-16564 | 地拉罗斯铁螯合物 Deferasirox (Fe3+ chelate) | 554435-83-5 | 10mM * 1mLin DMSO | 2063元 |