BRD9539
| 中文名称 | BRD9539 |
|---|---|
| 中文同义词 | G9A和PRC2抑制剂(BRD9539);化合物BRD9539;2-苯甲酰胺基-1-(3-苯基丙基)-1H-苯并[D]咪唑-5-羧酸;PRC2抑制剂 |
| 英文名称 | BRD-9539 |
| 英文同义词 | BRD 9539;BRD9539;BRD-9539;2-(BenzoylaMino)-1-(3-phenylpropyl)-1H-benziMidazole-5-carboxylic acid;1H-Benzimidazole-5-carboxylic acid, 2-(benzoylamino)-1-(3-phenylpropyl)-;2-Benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylic acid;Histone Methyltransferase,chromatin,PRC2,BRD9539,G9a,senescent,BRD-9539,BRD 9539,inhibit,H3K9,histones,Inhibitor,EHMT2 |
| CAS号 | 1374601-41-8 |
| 分子式 | C24H21N3O3 |
| 分子量 | 399.44 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂;对照品 |
| Mol文件 | 1374601-41-8.mol |
| 结构式 |  |
BRD9539 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | DMSO：可溶15mg/mL，澄清 |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
BRD9539 是一种组蛋白甲基转移酶 G9a 抑制剂，IC50 为 6.3 μM。BRD9539 还抑制 PRC2 活性，并且对 SUV39H1，NSD2 和 DNMT1 无活性。
|
G9a 6.3 μM (IC 50 ) |
PRC2
|
BRD9539 decreases ATP levels in a dose-dependent manner in HeLa cells.
BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration. However, BRD9539 has no activity in cell-based assays, presumably due to impaired cell permeability compared to that of BRD4770. In addition, the activities of 16 other chromatin-modifying enzymes and 100 kinases involved in cell-cycle regulation and cancer cell biology are tested for activity in the presence of 5 or 10 μM BRD9539; no activity is seen in any of these assays.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-15647 | BRD9539 BRD9539 | 1374601-41-8 | 5mg | 600元 |
| 2024/01/25 | HY-15647 | BRD9539 BRD9539 | 1374601-41-8 | 10mM * 1mLin DMSO | 660元 |