4-[[(1R,2R)-2-[(3R)-3-氨基-1-哌啶基]-2,3-二氢-1H-茚-1-基]氧基]-3-氯苯甲腈二盐酸盐
| 中文名称 | 4-[[(1R,2R)-2-[(3R)-3-氨基-1-哌啶基]-2,3-二氢-1H-茚-1-基]氧基]-3-氯苯甲腈二盐酸盐 |
|---|---|
| 中文同义词 | 4-[[(1R,2R)-2-[(3R)-3-氨基-1-哌啶基]-2,3-二氢-1H-茚-1-基]氧基]-3-氯苯甲腈二盐酸盐;化合物 T12849L;TRPC6抑制剂 |
| 英文名称 | TRPC6 inhibitor |
| 英文同义词 | TRPC6 inhibitor;CPA-1588;4-[[(1R,2R)-2-[(3R)-3-Amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile hydrochloride (1:2);TRCP6-IN-1 (hydrochloride);SAR7334 (hydrochloride);SAR7334 dihydrochloride;SAR7334 HYDROCHLORIDE ;TRCP 6 INHIBITOR;CPA-1588(dihydrochloride) |
| CAS号 | 1333207-63-8 |
| 分子式 | C21H24Cl3N3O |
| 分子量 | 440.79376 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1333207-63-8.mol |
| 结构式 | ![4-[[(1R,2R)-2-[(3R)-3-氨基-1-哌啶基]-2,3-二氢-1H-茚-1-基]氧基]-3-氯苯甲腈二盐酸盐 结构式](CAS/20180906/GIF/1333207-63-8.gif) |
4-[[(1R,2R)-2-[(3R)-3-氨基-1-哌啶基]-2,3-二氢-1H-茚-1-基]氧基]-3-氯苯甲腈二盐酸盐 性质
| 储存条件 | Store at -20°C |
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| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 粉末 |
IC50: 7.9 nM (TRPC6 currents)
SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca 2+ influx into cells with IC 50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca 2+ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes. SAR7334 (1 μM) has negligible effect on SOCE. SAR7334 dose-dependently reduces TRPC6 currents with an IC 50 of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents.
SAR7334 (10 mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-15699A | SAR7334 hydrochloride | 1 mg | 920元 | |
| 2024/01/25 | HY-15699A | 4-[[(1R,2R)-2-[(3R)-3-氨基-1-哌啶基]-2,3-二氢-1H-茚-1-基]氧基]-3-氯苯甲腈二盐酸盐 SAR7334 hydrochloride | 1333207-63-8 | 5mg | 2300元 |