硫酸依色林
中文名称 | 硫酸依色林 |
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中文同义词 | 硫酸毒豆碱;硫酸依色林;毒扁豆碱硫酸盐;扁豆半硫酸盐;硫酸毒扁豆盐;毒扁豆碱 半硫酸盐;依色林硫酸盐;伊色林 半硫酸盐 |
英文名称 | ESERINE SULFATE |
英文同义词 | (3as-cis)-amate(estersulfate(2:1)(salt);(3as-cis)-ylcarbamate(estersulfate(2:1);3-b)indole,1,2,3,3a,8,8a-hexahydro-5-hydroxy-1,3a,8-trimethyl-pyrrolo(meth;PHYSOSTIGMINE HEMISULFATE;PHYSOSTIGMINE HEMISULFATE SALT;PHYSOSTIGMINE SULFATE;Pyrrolo2,3-bindol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)-, sulfate (2:1) (salt);PHYSOSOTIGMINESULPHATE |
CAS号 | 64-47-1 |
分子式 | C30H44N6O8S |
分子量 | 648.77 |
EINECS号 | 200-585-4 |
相关类别 | Acetylcholine receptor |
Mol文件 | 64-47-1.mol |
结构式 |
硫酸依色林 性质
熔点 | 140° (after drying at 100°) |
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密度 | 1.0911 (rough estimate) |
折射率 | 1.7000 (estimate) |
储存条件 | 2-8°C |
溶解度 | DMSO(微溶)、乙醇(微溶)、甲醇(微溶) |
形态 | 粉末 |
水溶解性 | Soluble to 100 mM in water |
Merck | 13,7469 |
稳定性 | 吸湿性 |
CAS 数据库 | 64-47-1(CAS DataBase Reference) |
EPA化学物质信息 | Physostigmine sulfate (2:1) (64-47-1) |
Physostigmine hemisulfate (Eserine hemisulfate) 是一种可逆的乙酰胆碱酯酶 (AChE) 抑制剂。Physostigmine hemisulfate 可以透过血脑屏障并刺激中枢胆碱能神经传递。Physostigmine hemisulfate 能逆转阿尔茨海默病转基因小鼠的记忆缺陷。Physostigmine hemisulfate 也是抗胆碱能中毒的解毒剂。
Physostigmine hemisulfate (Eserine hemisulfate; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice.
Physostigmine hemisulfate (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats.
Animal Model: | Heterozygous transgenic mice (Tg(+) mice) |
Dosage: | 0.03, 0.1, and 0.3 mg/kg |
Administration: | SC; daily for 6 weeks |
Result: | Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals. |